Psychophysiological Interactions in a Visual Checkerboard Task: Reproducibility, Reliability, and the Effects of Deconvolution

Frontiers in Neuroscience
Xin Di, Bharat B Biswal

Abstract

Psychophysiological interaction (PPI) is a regression based method to study task modulated brain connectivity. Despite its popularity in functional MRI (fMRI) studies, its reliability and reproducibility have not been evaluated. We investigated reproducibility and reliability of PPI effects during a simple visual task, and examined the effect of deconvolution on the PPI results. A large open-access dataset was analyzed (n = 138), where a visual task was scanned twice with repetition times (TRs) of 645 and 1,400 ms, respectively. We first replicated our previous results by using the left and right middle occipital gyrus as seeds. Then regions of interest (ROI)-wise analysis was performed among 20 visual-related thalamic and cortical regions, and negative PPI effects were found between many ROIs with the posterior fusiform gyrus as a hub region. Both the seed-based and ROI-wise results were similar between the two runs and between the two PPI methods with and without deconvolution. The non-deconvolution method and the short TR run in general had larger effect sizes and greater extents. However, the deconvolution method performed worse in the 645 ms TR run than the 1,400 ms TR run in the voxel-wise analysis. Given the general simi...Continue Reading

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Citations

May 2, 2020·Brain Structure & Function·Hang YangBharat Biswal
Jul 28, 2020·Brain Imaging and Behavior·Xin DiBharat B Biswal
Jan 29, 2020·Nature Human Behaviour·Yin WangIngrid R Olson
Nov 20, 2020·Journal of Magnetic Resonance Imaging : JMRI·Alexander D CohenYang Wang

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Methods Mentioned

BETA
imaging technique

Software Mentioned

MATLAB
FSL ( FMRIB Software Library
SPM12

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