Psychophysiological stress response and memory in borderline personality disorder

European Journal of Psychotraumatology
M DuesenbergKatja Wingenfeld

Abstract

Background: Previously, we found that patients with borderline personality disorder (BPD) but not healthy controls (HC) showed improved memory retrieval after hydrocortisone administration. Objective: In this study, we examined whether increases in endogenous cortisol after psychosocial stress are associated with memory function in patients with BPD and in healthy individuals. Methods: We recruited 49 female patients with BPD and 49 female HC. All participants were exposed to a psychosocial stressor, the Trier Social Stress Test (TSST) and a control condition (Placebo (P-)TSST) in randomized order. Salivary cortisol, alpha amylase (sAA) and blood pressure were measured in response to stress. Subsequently, we examined free recall of a previously learned word list, autobiographical memory, and working memory. Results: We found a stress*time*group interaction effect for the cortisol response and for sAA to stress, which is mainly triggered by a slightly different increase in cortisol between groups from pre to post TSST. Furthermore, BPD patients showed a less pronounced increase in diastolic blood pressure compared to HC after stress. There was no effect of stress on memory performance in any tests, either in healthy controls or ...Continue Reading

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Citations

Jul 7, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophie MetzKatja Wingenfeld
Apr 10, 2019·Stress : the International Journal on the Biology of Stress·Jan NowackiKatja Wingenfeld
Jun 18, 2020·International Journal of Environmental Research and Public Health·Tao HuangWen-Chi Pan
Dec 31, 2020·International Journal of Environmental Research and Public Health·Chuk Ling Julian LaiMonique On Yee Leung
Feb 2, 2021·Borderline Personality Disorder and Emotion Dysregulation·Christian E DeuterKatja Wingenfeld

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