Psychosis in Parkinson's disease and parkinsonism in antipsychotic-naive schizophrenia spectrum psychosis: clinical, nosological and pathobiological challenges

Acta Pharmacologica Sinica
John L Waddington

Abstract

Following the formulation of operational criteria for the diagnosis of psychosis in Parkinson's disease, a neurodegenerative disorder, the past decade has seen increasing interest in such nonmotor psychopathology that appears to be independent of dopaminergic therapy. Similarly, there has been a resurgence of interest in motor aspects of the neurodevelopmental disorder of schizophrenia, including spontaneous parkinsonism that appears to be independent of antipsychotic treatment. This review first addresses the clinical and nosological challenges of these superficially paradoxical insights and then considers pathobiological challenges. It proposes that diverse modes of disturbance to one or more element(s) in a cortical-striatal-thalamocortical neuronal network, whether neurodegenerative or neurodevelopmental, can result in movement disorder, psychosis or both. It then proposes that time- and site-dependent dysfunction in such a neuronal network may be a generic substrate for the emergence of psychosis not only in Parkinson's disease and schizophrenia-spectrum disorders but also in other neuropsychiatric disorders in which psychosis, and sometimes movement disorders, can be encountered; these include substance abuse, cerebrovasc...Continue Reading

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Citations

Mar 24, 2020·Acta Pharmacologica Sinica·Xue-Chu Zhen, Hong-Yuan Chu
Jan 26, 2021·Frontiers in Psychology·Anastasia Pavlidou, Sebastian Walther
May 6, 2021·European Archives of Psychiatry and Clinical Neuroscience·Stefan FritzeDusan Hirjak
May 14, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jakob WasserthalDusan Hirjak

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