Psychosis of Alzheimer's disease: Neuropsychological and neuroimaging longitudinal study

International Journal of Geriatric Psychiatry
Fabrizia D'AntonioMaddalena Boccia

Abstract

Psychosis of Alzheimer's disease (AD) may represent a distinct disease phenotype; however, neuropsychological profile and neural basis linked to this phenotype have not yet been clarified. In this study, we aimed at detecting whether impairment in specific cognitive domains predicts the onset of psychosis in AD patients and what grey matter alterations, their location, and the rate of atrophy are associated with psychosis of AD. Longitudinal neuropsychological data from AD patients with and without psychosis were analysed to determine whether the neuropsychological profile can predict the onset of psychosis. A voxel-based morphometry (VBM) on longitudinal T1-weighted images was used to explore differences in grey matter volume and in the rate of atrophy between groups. Noncognitive domain predicted the psychosis onset. However, AD patients with psychosis exhibited greater atrophy in the right anterior-inferior temporal lobe, including the fusiform gyrus (cluster-p-family-wise error [pfwe] < 0.05; peak-p uncorrected [pUNC] < 0.001) as well as greater rate of atrophy in the right insula than nonpsychotic patients (cluster-pFWE = 0.075; peak-pUNC < 0.001). The anterior-inferior temporal lobe is part of the ventral visual stream, a...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1987·Italian Journal of Neurological Sciences·A OrsiniG Vallar
Dec 1, 1986·Journal of Clinical and Experimental Neuropsychology·W G Van GorpR Henry
Nov 1, 1994·Neurology·S E StarksteinR Leiguarda
Aug 1, 1996·Italian Journal of Neurological Sciences·A R GiovagnoliE Capitani
Nov 14, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·N HironoH Yamashita
Jan 29, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·D V Jeste, S I Finkel
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·R S WilsonD A Evans
May 13, 2003·Molecular Psychiatry·R A SweetD V Jeste
Jul 5, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I AppollonioP Nichelli
Oct 29, 2005·Dementia and Geriatric Cognitive Disorders·Seigo NakanoTatsuo Yamada
Dec 15, 2005·Neuroepidemiology·R S WilsonD A Evans
Sep 29, 2009·International Psychogeriatrics·Patricia A WilkoszRobert A Sweet
Feb 12, 2010·Brain : a Journal of Neurology·Robert A SweetUNKNOWN National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
Mar 4, 2010·Cognitive Neuropsychiatry·Claude M J Braun, Sabrina Suffren
Apr 9, 2010·Dementia and Geriatric Cognitive Disorders·Teruyuki MatsuokaKenji Fukui
Apr 16, 2010·Annals of the New York Academy of Sciences·Max Coltheart
Jun 19, 2012·Psychiatry Research·Zahinoor IsmailBenoit H Mulsant
Aug 23, 2012·Neuroscience and Biobehavioral Reviews·Suzanne J ReevesRobert J Howard
Oct 30, 2013·American Journal of Alzheimer's Disease and Other Dementias·Michael S RafiiPaul S Aisen
Mar 31, 2015·International Journal of Geriatric Psychiatry·Corinne E FischerUNKNOWN Alzheimer Disease Neuroimaging Initiative
Jun 9, 2015·Current Behavioral Neuroscience Reports·Pamela DeRosse, Katherine H Karlsgodt
Jul 19, 2016·Psychological Medicine·T T RaijJ Suvisaari
Jul 26, 2017·International Journal of Geriatric Psychiatry·Emma McLachlanSuzanne Reeves
Dec 7, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Winnie QianCorinne E Fischer
Feb 20, 2019·CPT: Pharmacometrics & Systems Pharmacology·Fabrizia D'AntonioJulie Bertrand

❮ Previous
Next ❯

Citations

Jun 10, 2021·Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association·Verónica G Walker, Elizabeth K Walker
Dec 10, 2021·Continuum : Lifelong Learning in Neurology·Parunyou Julayanont, Uma Suryadevara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.