Psychosocial Characteristics of Women with a Delayed Diagnosis of Turner Syndrome

The Journal of Pediatrics
Gabrielle E ReimannLeora E Comis

Abstract

To characterize the psychosocial profiles of adult women diagnosed with Turner syndrome before (early diagnosis) and at or after (late diagnosis) 13 years of age. Women with Turner syndrome ages 22 and older at evaluation (n = 110) participated in a cross-sectional study at the National Institutes of Health. Researchers performed nonparametric and logistic regression analyses to assess early and late diagnosis cohorts on measures of depression, substance use, and perceptions of competence and identity. Of study participants, 47% received a Turner syndrome diagnosis at or after age 13 years. Median age at diagnosis was 12.0 years (range, 0-43). Covariate-adjusted models revealed that women with late diagnoses had an increased likelihood of developing mild to severe depressive symptoms (OR,  7.36) and a decreased likelihood of being perceived as competent (OR, 0.26). Women with a late diagnosis also exhibited more frequent substance use compared with women with early diagnoses. These data suggest that Turner syndrome diagnoses received at or after age 13 years may contribute to adverse outcomes related to depression, substance use, and perceptions of competence. Delayed Turner syndrome diagnoses may place women and girls at risk ...Continue Reading

Associated Clinical Trials

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Citations

Feb 12, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Rebecca C Knickmeyer, Stephen R Hooper
Jul 20, 2019·Child: Care, Health and Development·Jeanne WolstencroftDavid Skuse
Aug 17, 2019·American Journal of Medical Genetics. Part a·Angela E LinClaus H Gravholt
Aug 15, 2021·American Journal of Medical Genetics. Part a·Sarah SwaugerIris Gutmark-Little

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