PMID: 15349006Sep 7, 2004Paper

Psychosocial functioning during the treatment of major depressive disorder with fluoxetine

Journal of Clinical Psychopharmacology
George I PapakostasM Fava

Abstract

Major depressive disorder (MDD) is associated with significant disability, having a profound impact on psychosocial functioning. Therefore, studying the impact of treatment on psychosocial functioning in MDD could help further improve the standard of care. Two hundred twenty-two MDD outpatients were treated openly with 20 mg fluoxetine for 8 weeks. The self-report version of the Social Adjustment Scale was administered at baseline and during the final visit. We then tested for the relationships between (1) self-report version of the Social Adjustment Scale scores at baseline and clinical response, (2) nonresponse, response and remission status and overall psychosocial adjustment at end point, (3) the number/severity of residual depressive symptoms and overall psychosocial adjustment at end point in responders, and (4) the time to onset of response and overall psychosocial adjustment at end point. An earlier onset of clinical response predicted better overall psychosocial functioning at end point (P = 0.0440). Responders (n = 128) demonstrated better overall psychosocial adjustment at end point than nonresponders (P = 0.0003), while remitters (n = 64) demonstrated better overall psychosocial adjustment at end point than nonremit...Continue Reading

References

Sep 1, 1976·Archives of General Psychiatry·M M Weissman, S Bothwell
Aug 31, 2000·The American Journal of Psychiatry·A A NierenbergM Fava
Jan 14, 2003·Comprehensive Psychiatry·George I PapakostasAndrew A Nierenberg
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Feb 6, 2004·General Hospital Psychiatry·George I PapakostasMaurizio Fava

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Citations

Nov 5, 2008·Current Psychiatry Reports·George I Papakostas, Richard C Shelton
Feb 3, 2009·Neuropsychiatric Disease and Treatment·J Craig NelsonRobert M Berman
Jun 22, 2010·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Michele Fornaro, Patricia Giosuè
Jun 12, 2014·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Christine Maria HörtnaglAlex Hofer
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·George I PapakostasMaurizio Fava
Nov 1, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Raymond W Lam
Aug 21, 2012·Comprehensive Psychiatry·Mark ZimmermanDaniela A Boerescu
May 13, 2011·Journal of Affective Disorders·Scott PattenSerge Beaulieu
Dec 7, 2007·Pediatric Clinics of North America·Kathi J Kemper, Scott Shannon
Dec 13, 2006·Psychiatry Research·George I PapakostasMaurizio Fava
Mar 30, 2007·Bipolar Disorders·Noel KennedyPatrick McKeon
Oct 12, 2013·Depression and Anxiety·Maurizio FavaMichael E Thase
Oct 9, 2007·Biological Psychiatry·George I PapakostasMichael E Thase
Dec 1, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Benedetto VitielloUNKNOWN TADS Team
Jan 18, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George I Papakostas
Jun 10, 2008·Journal of Affective Disorders·Jeffrey R VittenglRobin B Jarrett
Jun 28, 2005·Journal of Psychiatric Research·George I PapakostasMaurizio Fava
Nov 27, 2008·The Annals of Pharmacotherapy·Christian R DolderMorgan Snider
Apr 29, 2006·Journal of Psychopharmacology·Jonathan E Alpert
Apr 29, 2006·Journal of Psychopharmacology·Maurizio Fava

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