Psychotic mania as the solitary manifestation of neurosyphilis

Annals of General Psychiatry
Eun Hyun SeoHyung-Jun Yoon


Neurosyphilis remains a diagnostic challenge in current psychiatric practice because of its pleomorphic psychiatric manifestations. Although neurosyphilis can present with a wide range of psychiatric symptoms, psychotic mania as its solitary manifestation is an unusual phenomenon. A 46-year-old man, with no history of any psychiatric disorder, exhibited abruptly developed symptoms of psychotic mania. He was admitted to a psychiatric ward for further evaluation and treatment. Upon admission, his cognitive function was unimpaired, and the hyperactivity was not severe. Also, no abnormalities were found upon neurological examination and brain magnetic resonance imaging. He was initially diagnosed as bipolar disorder with psychotic features. On the 3rd day after admission, he was confirmed as having neurosyphilis by analysis of cerebrospinal fluid and treated with intravenous penicillin-in combination with blonanserin-an atypical antipsychotic drug. After 2 weeks of treatment, most of the symptoms had abated. The present case emphasizes that patients presenting with atypical psychiatric manifestation should be screened for possible syphilis, particularly in the absence of previous psychiatric history, and suggests that combination o...Continue Reading


Jan 1, 1969·The British Journal of Psychiatry : the Journal of Mental Science·K Dewhurst
Mar 5, 2002·The Journal of Clinical Psychiatry·David J KupferDebra A Stapf
Nov 19, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·M Timmermans, J Carr
Sep 20, 2007·Psychosomatics·Francis M Sanchez, Marc H Zisselman
Aug 14, 2008·The International Journal of Neuroscience·C H MitsonisD Vassilopoulos
Jun 27, 2009·General Hospital Psychiatry·Fabian FriedrichMartin Aigner
Jul 16, 2010·CNS Neuroscience & Therapeutics·Khalil G Ghanem
Jun 15, 2013·Neuropsychiatric Disease and Treatment·Tomomi TenjinNoboru Yamaguchi
Nov 20, 2013·The Journal of Neuropsychiatry and Clinical Neurosciences·Rochelle Melina Kinson, Lai Gwen Chan

Related Concepts

Mental Disorders
Bipolar Disorder
Cerebrospinal Fluid
Male Population Group
Penicillin G
Antipsychotic Agents
Hospital Admission

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists
Suzaily WahabSyazarina Sharis Othman
The Cochrane Database of Systematic Reviews
J M Rendell, J R Geddes
International Journal of Dermatology
Monika Czarnowska-Cubała
Duodecim; lääketieteellinen aikakauskirja
I Kujala
© 2021 Meta ULC. All rights reserved