Psychotic symptoms and apolipoprotein E genotypes in an elderly population

Biological Psychiatry
Y ForsellB Winblad

Abstract

Psychotic symptoms have been found to be more common in demented elderly persons. Genetic variation in the apolipoprotein E (APOE) gene is reported to be associated with variation in the risk of Alzheimer's dementia. This study reports on variables associated with psychotic symptoms including APOE, in demented and nondemented elderly persons. A population of 668 elderly persons was examined. APOE genotype was available in 309 individuals. Psychotic symptoms were found to be associated with dementia, a previous psychiatric history, female gender, being less educated, disability in daily living and institutionalisation. In the nondemented group, psychotic symptoms were equally common in subjects with or without the epsilon 4 present. In the demented subjects, psychotic symptoms were slightly more common, although not significant, in subjects without the epsilon 4 genotype. There was no statistical significant difference in APOE genotype between subjects with and without psychotic symptoms, stratified by dementic diagnosis.

References

Jan 1, 1993·Schizophrenia Bulletin·I ProhovnikN Willson
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Citations

Dec 1, 1998·Neuroscience Letters·T ShinkaiJ Nakamura
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sebastian KöhlerUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Mar 15, 2012·Brain Research Bulletin·Petroula Proitsi, John F Powell
May 12, 2011·International Journal of Alzheimer's Disease·Francesco PanzaAlberto Pilotto
Sep 10, 2011·International Journal of Geriatric Psychiatry·Grazia D'OnofrioAlberto Pilotto
Jul 6, 2010·Journal of Geriatric Psychiatry and Neurology·Svante OstlingMargda Waern
Apr 9, 2002·Journal of Geriatric Psychiatry and Neurology·Robert A SweetSteven T DeKosky
Sep 12, 2003·Journal of Geriatric Psychiatry and Neurology·Jordi ClarimónDavid Comas
May 13, 2003·Molecular Psychiatry·R A SweetD V Jeste

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