PMID: 9193967May 1, 1997Paper

Psychotropic drug use and cognitive decline among older men and women

International Journal of Geriatric Psychiatry
M J DealbertoL Berkman

Abstract

This epidemiological study focuses on cognitive change related to psychotropic drug use in a population-based sample of subjects aged 65 and over. Cognitive functioning was assessed in 1982 and 1988 by the Short Portable Mental Status by Pfeiffer, and cognitive decline was defined as an increase of more than 2 errors in 1988 relative to the 1982 assessment. Psychotropic drugs were classified into benzodiazepines and non-benzodiazepines. For both medications, four patterns of intake were considered: no use reported at both interviews, continuous use at both interviews, temporary use at the 1982 interview and new use at the 1988 interview. Depressive symptomatology was assessed by the Center for Epidemiologic Studies Depression Scale. The analysis was performed on 1200 subjects with no or minimal impairment at baseline for whom complete data were available. Univariate analyses showed cognitive decline associated with gender, level of education and new medical condition; it was also related to depressive symptomatology and psychotropic drug use. These two factors were the most strongly associated with decrease in performance in multivariate analyses. Cognitive decline differed according to class of psychotropic drugs and pattern o...Continue Reading

Citations

Oct 3, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·J EllulS Lovestone
Oct 10, 2012·BMJ : British Medical Journal·Sophie Billioti de GageAntoine Pariente
Mar 13, 2010·The American Journal of Emergency Medicine·Rebecca L Rao, Raquel M Schears

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