PTB or not PTB -- that is the question

FEBS Letters
K S YanMing Ming Zhou

Abstract

Phosphotyrosine binding (PTB) domains are structurally conserved modules found in proteins involved in numerous biological processes including signaling through cell-surface receptors and protein trafficking. While their original discovery is attributed to the recognition of phosphotyrosine in the context of NPXpY sequences -- a function distinct from that of the classical src homology 2 (SH2) domain -- recent studies show that these protein modules have much broader ligand binding specificities. These studies highlight the functional diversity of the PTB domain family as generalized protein interaction domains, and reinforce the concept that evolutionary changes of structural elements around the ligand binding site on a conserved structural core may endow these protein modules with the structural plasticity necessary for functional versatility.

References

Nov 17, 1995·The Journal of Biological Chemistry·G WolfS E Shoelson
Dec 16, 1994·Science·W M Kavanaugh, L T Williams
Jun 23, 1995·The Journal of Biological Chemistry·Z SongyangL C Cantley
Jul 1, 1995·Trends in Biochemical Sciences·P van der Geer, T Pawson
Sep 1, 1995·Nature Structural Biology·K M FergusonJ Schlessinger
Jun 23, 1994·Nature·H S YoonS W Fesik
Apr 1, 1996·Nature Structural Biology·M M ZhouS W Fesik
Jan 1, 1995·Progress in Biophysics and Molecular Biology·M M Zhou, S W Fesik
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·S C LiT Pawson
Feb 12, 1998·Science·T Pawson, J D Scott
Aug 1, 1997·Current Opinion in Chemical Biology·S E Shoelson
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Dhe-PaganonS E Shoelson
Nov 5, 1999·Trends in Biochemical Sciences·N BlombergM Saraste
Dec 23, 1999·Current Opinion in Structural Biology·J D Forman-Kay, T Pawson
Aug 11, 2000·Molecular and Cellular Biology·A MiyajimaT Enomoto

❮ Previous
Next ❯

Citations

Nov 27, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Feng ZhangCheng He
Jan 28, 2003·Current Opinion in Chemical Biology·Jong W Yu, Mark A Lemmon
Apr 3, 2010·Nature Protocols·Alexis KaushanskyGavin MacBeath
Jun 15, 2004·Nature Structural & Molecular Biology·Virginie GervaisArnaud Poterszman
Oct 7, 2003·Molecular Biology of the Cell·Masaaki NagaiMarilyn Gist Farquhar
Dec 18, 2003·Science's STKE : Signal Transduction Knowledge Environment·Simona PoloPier Paolo Di Fiore
Sep 20, 2006·Molecular and Cellular Biology·Matthew J SmithTony Pawson
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sanjay K MishraLinton M Traub
May 27, 2006·Molecular Systems Biology·Waltraud X SchulzeMatthias Mann
Nov 11, 2008·Experimental Cell Research·Floriana FrancalanciSaverio Francesco Retta
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·D K Strickland, S Ranganathan
Aug 31, 2007·Journal of Neurochemistry·Marie Germaine MamezaBarry B Kaplan
Jul 11, 2006·Trends in Biochemical Sciences·Han Remaut, Gabriel Waksman
Sep 6, 2005·Trends in Cell Biology·Aurea D Sousa, Richard E Cheney
Apr 14, 2005·Journal of Molecular Biology·J Peter GeyerHans Robert Kalbitzer
Feb 8, 2003·Current Biology : CB·Robert C LiddingtonJose M de Pereda
Nov 10, 2009·Advances in Enzyme Regulation·Katsuhisa KawaiHitoshi Yagisawa
Oct 29, 2015·International Immunology·Nadia Martin-BlancoMatilde Canelles
Jul 17, 2003·Science's STKE : Signal Transduction Knowledge Environment·Joseph Schlessinger, Mark A Lemmon
May 20, 2003·Molecular & Cellular Proteomics : MCP·Kazuya MachidaPeter Nollau
Sep 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Anne K SoutarLinton M Traub
Jun 27, 2003·The Journal of Biological Chemistry·Mikyung YunHee-Won Park
Aug 3, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dennis Dik-Long ChauKwok-Fai Lau
Feb 18, 2003·The Journal of Biological Chemistry·Alexandrine DerrienKirk M Druey
Apr 23, 2008·Current Protocols in Protein Science·Peter D SunJeffrey C Boyington
Oct 16, 2020·Gene·Stella C OgbuYong Jiang
Mar 6, 2002·The Journal of Biological Chemistry·Kelley S YanMing-Ming Zhou
Dec 13, 2005·Development·Romi BiswasE Richard Stanley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.