PTEN Inhibits High Glucose-Induced Phenotypic Transition in Podocytes

Journal of Cellular Biochemistry
Lingling XingHuijun Duan

Abstract

Accumulating evidence has suggested that podocytes undergo epithelial-mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the underlying mechanisms of EMT in podocyte are not well understood. PI3K/Akt pathway is involved in the progression of DN. In the present study, we demonstrated that PI3K/Akt pathway was activated in podocytes exposed to high glucose conditions, accompanied by down-regulation of the podocalyxin (PCX) and nephrin expression and up-regulation of the desmin and α-smooth muscle actin (α-SMA) expression. Inhibition of PI3K/Akt pathway by chemical LY294002 or Phosphase and tensin homology deleted on chromosome ten (PTEN) prevented the phenotypic transition. These findings indicate that PTEN/PI3K/Akt pathway mediates high glucose-induced phenotypic transition in podocytes.

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Citations

Feb 24, 2016·Biochemical and Biophysical Research Communications·Mengmeng DuGuijun Qin
Oct 26, 2016·Biochemical and Biophysical Research Communications·Xiaocui JiaoYanqing Chi
Nov 15, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Li XuLining Wang
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Feb 24, 2021·Journal of Cell Communication and Signaling·Baichao SunGuangdong Sun

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