PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.

The EMBO Journal
Sandra JuradoJosé A Esteban

Abstract

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is an important regulator of phosphatidylinositol-(3,4,5,)-trisphosphate signalling, which controls cell growth and differentiation. However, PTEN is also highly expressed in the adult brain, in which it can be found in dendritic spines in hippocampus and other brain regions. Here, we have investigated specific functions of PTEN in the regulation of synaptic function in excitatory hippocampal synapses. We found that NMDA receptor activation triggers a PDZ-dependent association between PTEN and the synaptic scaffolding molecule PSD-95. This association is accompanied by PTEN localization at the postsynaptic density and anchoring within the spine. On the other hand, enhancement of PTEN lipid phosphatase activity is able to drive depression of AMPA receptor-mediated synaptic responses. This activity is specifically required for NMDA receptor-dependent long-term depression (LTD), but not for LTP or metabotropic glutamate receptor-dependent LTD. Therefore, these results reveal PTEN as a regulated signalling molecule at the synapse, which is recruited to the postsynaptic membrane upon NMDA receptor activation, and is required for the modulation of synaptic activity durin...Continue Reading

References

Mar 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K D PhendR J Weinberg
Aug 11, 1998·Neuron·A NishimuneJ M Henley
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
May 4, 1999·Trends in Cell Biology·T Maehama, J E Dixon
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·X WuY E Whang
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Sheng
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shao Jun TangErin M Schuman
Jun 28, 2003·FEBS Letters·Caroline PendariesBernard Payrastre
Aug 26, 2003·Human Mutation·Charis Eng
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Maurizio CammalleriPietro Paolo Sanna
Dec 23, 2003·The European Journal of Neuroscience·Ronald S PetraliaRobert J Wenthold
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ingrid Ehrlich, Roberto Malinow
Apr 30, 2004·Journal of Neurophysiology·Sridhar Raghavachari, John E Lisman
May 19, 2004·FEBS Letters·Annette C SchmidRüdiger Woscholski
Aug 24, 2004·Nature Neuroscience·Bence RáczRichard J Weinberg
Aug 26, 2004·Developmental Biology·Bangyan StilesHong Wu
Sep 1, 2004·Brain Research. Molecular Brain Research·Claudia PerandonesMartín Radrizzani
Jun 7, 2005·Nature Neuroscience·Xi ChenDaniel R Storm
Aug 19, 2005·Genes & Development·Yi QinJ Julius Zhu
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacek JaworskiMorgan Sheng
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Paz RegaladoRobert C Malenka
Feb 24, 2006·Journal of Cell Science·Neil H ChadbornBritta J Eickholt
May 6, 2006·Neuron·Chang-Hyuk KwonLuis F Parada
Jun 16, 2006·Neuromolecular Medicine·Yue WangMark P Mattson
Jan 24, 2007·The European Journal of Neuroscience·Claudie HooperSimon Lovestone
Mar 3, 2007·Neuron·Stéphane PeineauGraham L Collingridge
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric A Horne, Mark L Dell'Acqua
Sep 6, 2007·Journal of Cellular Biochemistry·Challice L BonifantTodd Waldman
Nov 23, 2007·Journal of Cell Science·Tanja Tamguney, David Stokoe
Jul 29, 2008·Neuropharmacology·Graham L CollingridgeMichael Spedding

❮ Previous
Next ❯

Citations

Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Morgan Sheng, Ali Ertürk
May 11, 2012·Developmental Neuroscience·Tatiana M KazdobaGabriella D'Arcangelo
Aug 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew C WestonJohn W Swann
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshibumi Ueda, Yasunori Hayashi
Apr 7, 2011·Experimental & Molecular Medicine·Chang Hoon Cho
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Koichi TakeuchiR Suzanne Zukin
Jun 18, 2014·Molecular Neurobiology·Yoshibumi Ueda
Aug 13, 2013·Neuromolecular Medicine·Jia LuoKevin A Wilkinson
Jan 19, 2016·Nature Neuroscience·Shira KnafoJosé A Esteban
Feb 16, 2016·Molecular and Cellular Therapies·Lilian Enriquez-Barreto, Miguel Morales
Feb 26, 2016·Nature Neuroscience·Samuel Frere, Inna Slutsky
Feb 12, 2011·Trends in Molecular Medicine·Ted Weita LaiYu Tian Wang
Jun 19, 2015·Scientific Reports·Amber Petersen, Nashaat Z Gerges
Apr 10, 2014·The European Journal of Neuroscience·Bernadett BodaDominique Muller
Jun 21, 2015·European Journal of Cell Biology·Michael G LeitnerDominik Oliver
Mar 15, 2012·The Biochemical Journal·Xiaoqun Catherine ZhangNicholas K Tonks
Apr 29, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Amanda K TilotCharis Eng
Oct 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amber J McCartneyMichael A Sutton
Apr 30, 2014·Communicative & Integrative Biology·Pablo Garcia-Junco-Clemente, Peyman Golshani
Mar 9, 2012·Current Opinion in Neurobiology·Shira Knafo, José A Esteban
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·W N Marsden
Jan 30, 2013·Neuropharmacology·Thomas E Bartlett, Yu Tian Wang
Apr 20, 2014·Frontiers in Molecular Neuroscience·Patricia KreisBritta J Eickholt
Aug 26, 2014·Frontiers in Neuroanatomy·Carlos Gerardo DottiMaría Dolores Ledesma
Mar 29, 2014·Frontiers in Molecular Neuroscience·Candi L Lasarge, Steve C Danzer
Apr 16, 2013·Neuropharmacology·Qiang Zhou, Morgan Sheng
Jun 13, 2017·Cellular & Molecular Immunology·Lang Chen, Deyin Guo
Feb 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rafael Pulido
Jun 4, 2016·Journal of Cell Science·Mónica Fernández-MonrealJosé A Esteban
Jul 16, 2015·Stroke; a Journal of Cerebral Circulation·Yongjun SunZibin Gao
Mar 14, 2013·Nature Reviews. Neuroscience·Matthias Kneussel, Wolfgang Wagner
Jun 1, 2014·EMBO Molecular Medicine·Mauricio G MartinCarlos G Dotti
Oct 8, 2014·Physiological Reviews·Jeremy M HenleyKevin A Wilkinson
Oct 23, 2019·Cold Spring Harbor Perspectives in Medicine·Glenn R Masson, Roger L Williams

❮ Previous
Next ❯

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