PTEN: Multiple Functions in Human Malignant Tumors

Frontiers in Oncology
Michele MilellaLudovica Ciuffreda

Abstract

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor suppressor in a PI3K-independent manner. Indeed, the PTEN network regulates a broad spectrum of biological functions, modulating the flow of information from membrane-bound growth factor receptors to nuclear transcription factors, occurring in concert with other tumor suppressors and oncogenic signaling pathways. PTEN acts through its lipid and protein phosphatase activity and other non-enzymatic mechanisms. Studies conducted over the past 10 years have expanded our understanding of the biological role of PTEN, showing that in addition to its ability to regulate proliferation and cell survival, it also plays an intriguing role in regulating genomic stability, cell migration, stem cell self-renewal, and tumor microenvironment. Changes in PTEN protein levels, location, and enzymatic activity through various molecular mechanisms can generate a continuum of functional PTEN levels in inherited syndromes, sporadic cancers, and other diseases. PTEN activity can indeed, be modulated by mutations, epigenetic silencing, transcriptional repression, aberrant protei...Continue Reading

References

Aug 11, 1998·Nature Genetics·A Di CristofanoP P Pandolfi
Sep 23, 1998·Nature·I PalmeroM Serrano
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K PodsypaninaR Parsons
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·L C Cantley, B G Neel
Feb 29, 2000·Cell·A Di Cristofano, P P Pandolfi
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·X WuY E Whang
Apr 25, 2000·The Journal of Biological Chemistry·N NakashimaJ M Olefsky
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·S WenD L Durden
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Kwabi-AddoM Ittmann
Nov 2, 2001·Biochemical and Biophysical Research Communications·V A MosserM J Quon
Dec 1, 2001·The Journal of Biological Chemistry·Santiago VazquezRoger J W Truscott
Feb 23, 2002·Cellular Signalling·Nick R Leslie, C Peter Downes
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Jun 14, 2002·Cell·Miho Iijima, Peter Devreotes
Sep 26, 2002·FEBS Letters·Susan J MillerBenjamin G Neel
Feb 13, 2003·Biochemistry·Xinhua HuangRonald L Mellgren
Aug 26, 2003·Human Mutation·Charis Eng
Oct 1, 2003·The Journal of Biological Chemistry·Roger A MooreheadRama Khokha
Dec 24, 2003·PLoS Biology·Lloyd C TrotmanPier Paolo Pandolfi
Jun 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew J AguirreLynda Chin
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle Sansal, William R Sellers
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Salma KhanShikha Bose
Nov 27, 2004·The New England Journal of Medicine·Pier Paolo Pandolfi
Jan 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Koichi OkumuraWebster K Cavenee
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Mar 16, 2005·Cancer Cell·Raymond H KimTak W Mak

❮ Previous
Next ❯

Citations

Jan 9, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaoyu ChenChangqing Yang
Jan 17, 2016·Biochimica Et Biophysica Acta·Mart BittremieuxGeert Bultynck
Jun 17, 2016·Molecular & Cellular Oncology·Nuala McCabeRichard D Kennedy
Oct 27, 2015·Apoptosis : an International Journal on Programmed Cell Death·Chong ZengFeiyue Xing
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Saya H EbbesenScott W Lowe
Apr 14, 2016·Future Oncology·Vadim V Maximov, Rami I Aqeilan
Apr 7, 2015·Methods : a Companion to Methods in Enzymology·Rafael Pulido
Aug 1, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Martin WartenbergEva Karamitopoulou
Oct 4, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eryong LuChao Zhang
Nov 26, 2015·PloS One·Nicola De FranceschiJeroen Pouwels
Feb 23, 2017·Mucosal Immunology·L C Kottyan, M E Rothenberg
Jan 28, 2017·British Journal of Pharmacology·Zhi-Feng ZhangQi Wan
Jun 13, 2017·Cellular & Molecular Immunology·Lang Chen, Deyin Guo
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ayesha KhalidSaba Khaliq
Jul 13, 2017·Cell Biology International·Xin ZhangWenguang Liu
Jan 20, 2018·Cancers·Fabiana ConciatoriMichele Milella
Apr 6, 2018·Future Medicinal Chemistry·Kirti S PrabhuShahab Uddin
Jan 25, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tonglei LiuHuayou Luo
Dec 30, 2016·Molecular and Cellular Biology·Elizabeth A Sierra PotchanantGrzegorz Nalepa
Jan 23, 2019·The Journal of Pharmacy and Pharmacology·Jun ShenGuanghui Pan
Feb 20, 2018·Molecular Cancer·Qinlian JiaoYun-Shan Wang
May 16, 2019·Cold Spring Harbor Perspectives in Biology·Sarah J Roberts-ThomsonGregory R Monteith
Sep 5, 2019·Cells·João M A DelouHelena L Borges
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Katie A ThiesMichael C Ostrowski
Feb 17, 2017·Biochemical Society Transactions·Vladislav KorobeynikovErica A Golemis
Dec 17, 2019·Antioxidants & Redox Signaling·Jia Yu LeungReshma Taneja
Mar 9, 2020·Journal of Cancer Research and Clinical Oncology·Jianrong LiuJinrong Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ubiquitination
sumoylation
acetylation
histone acetylation

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

Expert Review of Neurotherapeutics
Daphne Haas-Kogan, David Stokoe
International Journal of Oncology
Atsuko NakanishiSatoru Matsuda
© 2021 Meta ULC. All rights reserved