PTEN mutations in uterine sarcomas

Gynecologic Oncology
F AmantE J Van Rensburg

Abstract

Uterinesarcomas comprise three main types: carcinosarcomas, leiomyosarcomas, and endometrial stromal sarcomas. Carcinosarcomas are highly aggressive neoplasms with a biphasic histology of carcinomatous and sarcomatous elements. It is now generally accepted that carcinosarcomas are biphasic tumors that have to be regarded as endometrial carcinomas where metaplasia occurs. Mutations of the PTEN tumor suppressor gene, located on 10q23, play a significant role in the pathogenesis of the endometrioid type of endometrial carcinoma. Loss of heterozygosity of chromosome 10q has been reported in uterine leiomyosarcoma. Since little is known about the molecular pathobiology, our goal was to investigate the potential role of the PTEN gene in the carcinogenesis of uterine sarcomas. We examined 21 carcinosarcomas, 21 leiomyosarcomas, and 5 endometrial stromal sarcomas using exon-by-exon polymerase chain reaction-single-strand conformation polymorphism analysis. Overall 8.5% (4/47) of uterine sarcomas were found to harbor somatic PTEN mutations. Of these, approximately 17% (3/18) were carcinosarcomas with endometrioid-type carcinoma components and approximately 5% (1/21) were leiomyosarcomas. No mutations were detected in carcinosarcomas wit...Continue Reading

References

Jun 1, 1988·Cancer Genetics and Cytogenetics·P Dal CinA A Sandberg
Nov 1, 1988·Cancer Genetics and Cytogenetics·P Dal CinA A Sandberg
Aug 1, 1994·Gynecologic Oncology·S de VosP Koeffler
Feb 15, 1993·Cancer·R LaxmanC A Griffin
Jan 1, 1997·Cancer Genetics and Cytogenetics·H T LynchJ Lynch
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Nov 5, 1997·Nature Genetics·D KongA Horii
Jan 19, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Y L ZhaiS Fujii
Nov 7, 1999·The American Journal of Pathology·M EstellerJ G Herman
Feb 29, 2000·Cell·A Di Cristofano, P P Pandolfi
Jun 8, 2000·Journal of the National Cancer Institute·G L MutterC Eng
Aug 3, 2000·Human Mutation·D Bonneau, M Longy
May 12, 2001·American Journal of Obstetrics and Gynecology·J M LancasterA Berchuck
Jul 5, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F AmantE J Van Rensburg

❮ Previous
Next ❯

Citations

Apr 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Magdalena KowalewskaMariusz Bidzinski
May 17, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Renske A de JongHarry Hollema
May 10, 2013·The New England Journal of Medicine·Richard T PensonEsther Oliva
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S AritaS Nomura
Jul 24, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kari J Brewer SavannahDina Lev
Sep 21, 2004·Gynecologic and Obstetric Investigation·Hüsnü GökaslanFatih Durmuşoğlu
Mar 19, 2013·Oncogene·J StebbingG Giamas
Aug 21, 2007·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
May 29, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A CoosemansF Amant
Mar 31, 2005·Cancer Genetics and Cytogenetics·Uma N M RaoSydney Finkelstein
Oct 27, 2011·Gynecologic Oncology·Jasmine H FrancisDavid H Abramson
Aug 16, 2016·Surgical Pathology Clinics·Lauren L Ritterhouse, Brooke E Howitt
Sep 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeannette R WongRuth A Kleinerman
Jan 26, 2017·American Journal of Clinical Oncology·Bismarck OdeiDavid K Gaffney
Feb 16, 2006·International Journal of Cancer. Journal International Du Cancer·Sanna K Ylisaukko-ojaLauri A Aaltonen
Nov 13, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Todd W KelleyJohn R Goldblum
Nov 13, 2018·Frontiers in Oncology·Katia C GenadryCorinne M Linardic
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Tsuyoshi SaitoMasazumi Tsuneyoshi
Nov 28, 2020·Scientific Reports·Eucharist H S KunKwong-Kwok Wong
Oct 18, 2019·Seminars in Cancer Biology·Holly E Barker, Clare L Scott
Mar 27, 2004·Archives of Pathology & Laboratory Medicine·Riccardo RicciLuigi Maria Larocca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.