Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo.

Developmental Biology
Joshua BloomekatzKathryn V Anderson

Abstract

Pten, the potent tumor suppressor, is a lipid phosphatase that is best known as a regulator of cell proliferation and cell survival. Here we show that mouse embryos that lack Pten have a striking set of morphogenetic defects, including the failure to correctly specify the anterior-posterior body axis, that are not caused by changes in proliferation or cell death. The majority of Pten null embryos express markers of the primitive streak at ectopic locations around the embryonic circumference, rather than at a single site at the posterior of the embryo. Epiblast-specific deletion shows that Pten is not required in the cells of the primitive streak; instead, Pten is required for normal migration of cells of the Anterior Visceral Endoderm (AVE), an extraembryonic organizer that controls the position of the streak. Cells of the wild-type AVE migrate within the visceral endoderm epithelium from the distal tip of the embryo to a position adjacent to the extraembryonic region. In all Pten null mutants, AVE cells move a reduced distance and disperse in random directions, instead of moving as a coordinated group to the anterior of the embryo. Aberrant AVE migration is associated with the formation of ectopic F-actin foci, which indicates...Continue Reading

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Citations

Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew J Stower, Shankar Srinivas
Jan 29, 2016·Seminars in Cell & Developmental Biology·Ann E Sutherland
Aug 15, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Nils J HerionClaudia Kappen
Apr 25, 2015·Developmental Biology·Yeonsoo YoonJaime A Rivera-Pérez
Sep 5, 2015·Journal of Signal Transduction·Travis J Jerde
Nov 26, 2015·Scientific Reports·J Michael SalbaumClaudia Kappen
Apr 8, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yue MengXiang-Xi Xu
Aug 11, 2018·Annual Review of Cell and Developmental Biology·Hui Ting Zhang, Takashi Hiiragi
Feb 8, 2021·Journal of Insect Physiology·Shi-Hong GuPei-Ling Lin

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