Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

Free Radical Biology & Medicine
Wei WangLing-Dong Kong

Abstract

High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) as a biomarker of oxidative stress in renal cortex of fructose-fed rats, which correlated with podocyte injury and albuminuria in metabolic syndrome. Fructose feeding increased miR-377 expression, decreased superoxide dismutase (SOD) expression and activity, and caused O2(-) and H2O2 overproduction in kidney cortex or glomeruli of rats. This reactive oxygen species induction increased p38 MAPK phosphorylation and thioredoxin-interacting protein (TXNIP) expression and activated the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome to produce interleukin-1β in kidney glomeruli of fructose-fed rats. These pathological processes were further evaluated in cultured differentiated podocytes exposed to 5mM fructose, or transfected with miR-377 mimic/inhibitor and TXNIP siRNA, or co-incubated with p38 MAPK inhibitor, demonstrating that miR-377 overexpression activates the O2(-)/p38 MAPK/TXNIP/NLRP3 inflammasome pathway to promote oxidative stress and inflammation in fructose-induced podocyte injury. Antioxidants pterostilbene ...Continue Reading

References

Jan 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·C D HOLDSWORTH, A M DAWSON
Oct 9, 2003·Kidney International·Tsutomu KobayashiHidehito Kotani
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sergey V BrodskyMichael S Goligorsky
Sep 24, 2004·Kidney & Blood Pressure Research·Barbara LewkoJan Stepinski
Oct 22, 2004·Kidney International·José G van den BergSandrine Florquin
Jul 1, 2005·Journal of the American Society of Nephrology : JASN·Masao KoshikawaKazuwa Nakao
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yui-Pong SiuTze-Hoi Kwan
Feb 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eun-Young LeeSae Yong Hong
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·M Amarnath Satheesh, L Pari
Jan 24, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Laurent SpahrAntoine Hadengue
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Sirirat ReungjuiTakahiko Nakagawa
Jan 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shreeram AkileshAndrey S Shaw
Apr 30, 2008·Metabolism: Clinical and Experimental·Michiaki FukuiNaoto Nakamura
May 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chia-Chao WuYuh-Feng Lin
May 23, 2008·Kidney International·Anurag Kumar SinghManoocher Soleimani
Jul 18, 2008·Journal of the American Society of Nephrology : JASN·Shirong ZhengPaul N Epstein
Aug 22, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiang WangRichard J Quigg
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Pietro CirilloYuri Y Sautin
May 22, 2009·American Journal of Physiology. Renal Physiology·Tomoki KosugiTakahiko Nakagawa
Jan 15, 2010·American Journal of Physiology. Renal Physiology·Takahiro NakayamaTakahiko Nakagawa
Sep 20, 2011·Apoptosis : an International Journal on Programmed Cell Death·Lu ZhangLiangke Chen
Jun 2, 2012·Journal of the American Society of Nephrology : JASN·Yoshihisa OgawaKazuwa Nakao
Aug 7, 2012·Molecular Nutrition & Food Research·Yun-Wei ShiLing-Dong Kong
Nov 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lvyi ChenXukun Deng
Jan 25, 2013·Kidney International·Carole OudotCaroline Rugale
Feb 23, 2013·Journal of Toxicology·Daniel M RicheMichael Griswold
Feb 28, 2013·International Journal of Molecular Sciences·Shunjiang XuQingfu Zhang
May 22, 2013·Oxidative Medicine and Cellular Longevity·Denise McCormack, David McFadden
Jun 5, 2013·Journal of Pharmacological and Toxicological Methods·Vishal DiwanLindsay Brown
Jun 19, 2013·Free Radical Biology & Medicine·Mitsuo KatoRama Natarajan
Sep 28, 2013·BMC Complementary and Alternative Medicine·Jhankar D Acharya, Saroj S Ghaskadbi

❮ Previous
Next ❯

Citations

Oct 21, 2015·Free Radical Research·Maria Beatriz MonteiroMaria Lúcia Corrêa-Giannella
Sep 24, 2015·Molecular Nutrition & Food Research·Xiao-Qin DingLing-Dong Kong
Nov 26, 2015·Frontiers in Pharmacology·Bo-Zong ShaoChong Liu
Jun 1, 2016·Molecular Diagnosis & Therapy·Amir Abbas MomtaziAmirhossein Sahebkar
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jinyang ShenChangrun Guo
Jan 23, 2017·Trends in Molecular Medicine·Meghana N PatelSeth L Masters
Jan 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying XuFeng Pan
Mar 31, 2017·Immunology and Cell Biology·Jin Kyung KimEun-Kyeong Jo
Jul 1, 2017·Annals of the New York Academy of Sciences·Avinash KumarAnait S Levenson
May 23, 2018·International Journal of Immunopathology and Pharmacology·Maria Fátima de Paula RamosNestor Schor
Aug 31, 2018·Journal of Cellular Biochemistry·Habib YaribeygiAmirhossein Sahebkar
Sep 21, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Ling-Yan ChenChao-Ke Tang
Apr 19, 2017·Journal of Cellular Biochemistry·Dong ZhengKeming Xie
Apr 4, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Masoumeh AlishahiSeyed Esmaeil Khoshnam
Jun 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Miaomiao XinJibo Wang
Aug 21, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S Bilgic, I Armagan
May 26, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei XiongChun Zhang
May 13, 2020·Clinical Nutrition Research·Kourosh SayehmiriEnayat Anvari
Apr 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina BoxbergerUwe K Zettl
Dec 25, 2019·Oxidative Medicine and Cellular Longevity·Lin-Lin KangLing-Dong Kong
Mar 25, 2020·Phytotherapy Research : PTR·Wenqiang ZhangYue Hou
Oct 11, 2019·Precision Clinical Medicine·Qinqin PuMin Wu
Sep 24, 2020·International Journal of Molecular Sciences·Adam WłodarskiAgnieszka Śliwińska
Jan 12, 2021·Modern Rheumatology·Hamza Malik Okuyan, Mehmet A Begen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.