PMID: 9186558Apr 1, 1997Paper

Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities

The Journal of Antibiotics
M EnglerU Brandt

Abstract

Pterulinic acid (1) and pterulone (2), two novel halogenated antibiotics, were isolated from fermentations of Pterula sp. 82168. Both compounds exhibited significant antifungal and weak or no cytotoxic activities. 1 and 2 are effective inhibitors of eucaryotic respiration. The target of the antibiotics resides within the mitochondrial NADH:ubiquinone oxidoreductase (complex I).

Citations

Dec 20, 2003·Organic & Biomolecular Chemistry·Philippe LemaireJean-Pierre Vors
Jan 17, 2009·The Journal of Antibiotics·In-Kyoung LeeBong-Sik Yun
Jun 4, 2015·Natural Product Reports·Peter Spiteller
Jul 8, 2008·Chemistry : a European Journal·Peter Spiteller
Dec 17, 2009·The Journal of Organic Chemistry·Marjorie BruderChristopher J Moody
Jun 19, 1998·Biochimica Et Biophysica Acta·M Degli Esposti
Jun 25, 2021·The Journal of Antibiotics·Manabu KawadaTomokazu Ohishi
Apr 8, 2015·The Journal of Organic Chemistry·Ewen D D CalderAndrew Sutherland

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