PTH analogues and osteoporotic fractures

Expert Opinion on Biological Therapy
Harald J J Verhaar, Willem F Lems

Abstract

At present there are two parathyroid hormone (PTH) analogues (PTH 1 - 34 and PTH 1 - 84) registered for the treatment of established osteoporosis in postmenopausal women (PTH 1 - 34 and PTH 1 - 84) and in men (PTH 1 - 34 only) who are at increased risk of having a fracture. The efficacy and safety of PTH 1 - 34 and PTH 1 - 84 in the management of osteoporosis is evaluated by reviewing published literature and presentations from scientific meetings through to 2010. This review focuses on data on fracture risk reduction and safety endpoints of PTH analogues. The adverse reactions reported most are nausea, pain in the extremities, headache and dizziness. Exogenous PTH analogues, given as daily subcutaneous injections, stimulate bone formation, increase bone mass and bone strength, and improve calcium balance. In postmenopausal women with osteoporosis, PTH analogues reduced the risk of vertebral (PTH 1 - 34 and PTH 1 - 84) and non-vertebral fractures (only PTH 1 - 34). In men and women with glucocorticosteroid-induced osteoporosis, PTH 1 - 34 reduced the risk of vertebral fractures. In general, PTH analogues are well tolerated with an acceptable safety profile: they can be used for the prevention and treatment of fractures in postm...Continue Reading

References

Nov 1, 1992·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C CooperL J Melton
Jan 1, 1985·Epidemiologic Reviews·S R CummingsK J O'Dowd
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H D NiallJ T Potts
Jan 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S OrwollG A Gaich
Nov 11, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yebin JiangErik F Eriksen
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard PrinceBruce H Mitlak
Aug 10, 2005·Archives of Internal Medicine·Michael R McClungErik F Eriksen
Sep 6, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Michael C NevittJohn H Krege
Mar 7, 2006·Current Rheumatology Reports·Felicia Cosman
Jul 11, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N K ArdenM Goater
Sep 14, 2006·Calcified Tissue International·T P van Staa
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Mar 7, 2007·Annals of Internal Medicine·Susan L GreenspanUNKNOWN Treatment of Osteoporosis with Parathyroid Hormone Study Group
Oct 31, 2007·Arthritis and Rheumatism·Willem F Lems
Nov 16, 2007·The New England Journal of Medicine·Philip N Sambrook
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard EastellClaus C Glüer
Dec 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J O Clausen

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Citations

Jun 2, 2011·BMC Medicine·Rozalia DimitriouPeter V Giannoudis
May 26, 2012·Indian Journal of Endocrinology and Metabolism·Marilyn Lee Cheng, Vishal Gupta
Jun 6, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mohammad Reza ZarrinkalamRobert J Moore
Jul 14, 2011·Nature Reviews. Endocrinology·Marius E Kraenzlin, Christian Meier
Aug 19, 2016·Frontiers in Endocrinology·Frans Alexander JacobsWilliam Frank Ferris
May 3, 2011·Molecular and Cellular Biochemistry·Ye TianMing He
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuanjin ChenYunxia Jiang

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