PTK7 as a novel marker for favorable gastric cancer patient survival

Journal of Surgical Oncology
Yi LinJiafu Ji

Abstract

Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer. PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed. PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012). Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.

References

Jun 11, 1997·International Journal of Cancer. Journal International Du Cancer·D J EastyD C Bennett
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carsten Müller-TidowHubert Serve
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hideki EndohTetsuya Mitsudomi
Jul 2, 2004·Nature·Xiaowei LuMarc Tessier-Lavigne
Nov 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Todd A Alonzo
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
May 13, 2008·Biochemical and Biophysical Research Communications·Won-Sik ShinSeung-Taek Lee
Jul 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A CervantesE Rodríguez-Braun
Nov 14, 2008·Development·Iryna Shnitsar, Annette Borchers
Apr 23, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Jaffer A AjaniUNKNOWN NCCN Gastric Cancer Panel
Jan 14, 2011·The Journal of Surgical Research·Junko MatsuokaKosei Hirakawa
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 19, 2011·Cell Cycle·Anne-Catherine LhoumeauJean-Paul Borg
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Viktoria S WarnekeChristoph Röcken
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 21, 2011·The EMBO Journal·Hanna PeradziryiNicholas S Tolwinski
Nov 4, 2011·Annals of Surgical Oncology·Yun-Suhk SuhWoo Ho Kim

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Citations

Jul 22, 2016·Cancers·Norris Ray Dunn, Nicholas S Tolwinski
Apr 21, 2017·Frontiers in Cell and Developmental Biology·Hanna BergerAnnette Borchers
Apr 5, 2019·Disease Markers·Jun-Jie SunFeng-Xia Xue
Apr 27, 2017·Molecular Cancer Research : MCR·Shanta M MesserliRatan D Bhardwaj
Sep 1, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Orit JacobsonXiaoyuan Chen
Oct 9, 2021·Scientific Reports·Estefanía SiccoHugo Cerecetto

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