PTPIP51-a myeloid lineage specific protein interacts with PTP1B in neutrophil granulocytes.

Blood Cells, Molecules & Diseases
Alexander BrobeilMonika Wimmer

Abstract

Protein tyrosine phosphatase interacting protein 51 (PTPIP51) was identified as an in vitro interacting partner of protein tyrosine phosphatase 1B (PTP1B) and T-cell protein tyrosine phosphatase (TCPTP). The full-length form of PTPIP51 encompasses 470aas and has a molecular weight of 52kDa. The physiological function is poorly understood but an involvement in differentiation processes and apoptosis has been suggested. Preliminary observations suggested differences in PTPIP51 expression in blood cells. To analyze a possible involvement of PTPIP51 in hematopoietic processes, we studied its expression in samples of peripheral venous blood (PVB), umbilical cord blood (UCB) and human bone marrow (HBM). In both, PVB and UCB PTPIP51 expression was restricted to neutrophil granulocytes. In HBM samples, besides in mature neutrophil ganulocytes PTPIP51 protein and mRNA was present in myeloid precursor cells of neutrophils. The expression of PTPIP51 in neutrophil granulocytes was corroborated by immunoblot analysis exhibiting different molecular weight forms of PTPIP51 protein. Anti-peptide antibodies, identifying specific regions of the PTPIP51 protein (C-terminus, N-terminus and aas114-129) revealed a distinct isoform expression pattern...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 27, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C Carter-SuJ Herrington
Apr 6, 2004·Developmental and Comparative Immunology·Daniel R BarredaMiodrag Belosevic
Apr 21, 2004·Immunology·Terri N Ellis, Blaine L Beaman
Aug 19, 2004·Cellular and Molecular Life Sciences : CMLS·A Rose, I Meier
Sep 17, 2004·Journal of Cell Science·Cai HuangMichael D Schaller
Dec 21, 2004·Histochemistry and Cell Biology·Albrecht StenzingerMonika Wimmer
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Nobukazu Araki
May 12, 2006·Cell Cycle·Krista M Heinonen, Michel L Tremblay
Dec 18, 2007·Histochemistry and Cell Biology·David MaerkerMonika Wimmer
Jan 10, 2008·Blood·Donald Metcalf
Feb 1, 2008·Cancer Metastasis Reviews·Matthew StuibleMichel L Tremblay
Aug 22, 2008·Blood·Xiaoqing LuIzidore S Lossos
Nov 18, 2008·Journal of Cellular and Molecular Medicine·P KochM Wimmer
Jan 7, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Justus BaropMonika Wimmer
Feb 21, 2009·Journal of Cellular Biochemistry·Zhao-Jun LiuOmaida C Velazquez
Apr 23, 2009·Cell Communication and Signaling : CCS·Gerald ThielOliver G Rössler
Oct 22, 2009·The Journal of Comparative Neurology·P KochM Wimmer

❮ Previous
Next ❯

Citations

Mar 4, 2011·Cell and Tissue Research·Alexander BrobeilMonika Wimmer
May 1, 2012·Cell Biochemistry and Biophysics·Alexander BrobeilMonika Wimmer
Dec 2, 2011·Human Molecular Genetics·Kurt J De VosChristopher C J Miller
Apr 22, 2015·Biomolecules·Alexander BrobeilMonika Wimmer
Jul 25, 2013·Critical Reviews in Biochemistry and Molecular Biology·Matthew FeldhammerMichel L Tremblay
Dec 17, 2014·Molecular and Cellular Neurosciences·A BrobeilM Wimmer
May 29, 2012·Blood Cells, Molecules & Diseases·Jessica E PrenniChristine S Olver
Jan 27, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M BobrichM Wimmer
Jun 23, 2011·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Enrico Bucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Related Papers

International Journal of Obesity : Journal of the International Association for the Study of Obesity
M A BobrichMonika Wimmer
The Journal of Comparative Neurology
P KochMonika Wimmer
© 2021 Meta ULC. All rights reserved