Pu-erh Tea Regulates Fatty Acid Metabolism in Mice Under High-Fat Diet

Frontiers in Pharmacology
Fengjie HuangWei Jia

Abstract

Pu-erh tea has been extensively reported to possess lipid lowering effects but the underlying mechanisms remained unclear. Free fatty acids (FFAs) are generally correlated with the development of obesity, leading to increased risk for type 2 diabetes mellitus and cardiovascular diseases. To investigate whether Pu-erh tea treatment alters FA metabolism, we treated HFD induced obese mice with Pu-erh tea for 22 weeks and analyzed FFA profiles of experimental mice using a UPLC-QTOF-MS platform. Results showed remarkable changes in metabolic phenotypes and FFA compositions in mice treated with or without Pu-erh tea. HFD induced a marked obese phenotype in mice as revealed by significantly increased body weight, liver and adipose tissue weight, lipid levels in serum and liver, and these parameters were markedly reduced by Pu-erh tea treatment. Several FFA or FFA ratios, such as DGLA, palmitoleic acid, and OA/SA ratio, were significantly increased while the levels of SA/PA and AA/DGLA were significantly reduced in HFD-induced obese mice. Interestingly, these differential FFAs or FFA ratios were previous identified as key markers in human obese subjects, and their changes observed in the HFD group were reversed by Pu-erh tea treatment....Continue Reading

References

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R L KolotkinG R Williams
Feb 8, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Guenther Boden
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Apr 12, 2016·Scientific Reports·Xiaojiao ZhengWei Jia
Dec 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Linjing ZhaoWei Jia

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