PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1.

Blood
L A Garrett-SinhaM C Simon

Abstract

Previously it was shown that the Ets proteins, PU.1 and Spi-B, exhibit functional redundancy in B lymphocytes. To investigate the possibility that PU.1 or Spi-B or both share overlapping roles with Ets-1 or Elf-1, PU.1(+/-)Ets-1(-/-), PU.1(+/-)Elf-1(-/-), and Spi-B(-/-)Ets-1(-/-) animals were generated. No blood cell defects were observed in these animals except those previously reported for Ets-1(-/-) mice. Therefore, no genetic overlap was detected between PU.1 or Spi-B with Ets-1 or Elf-1. In contrast, the results confirmed functional redundancy for PU.1 and Spi-B in that PU.1(+/-)Spi-B(-/-) bone marrow progenitors yielded smaller colonies in methylcellulose cultures than did wild-type, PU.1(+/-) or Spi-B(-/-) progenitors. In addition, PU.1(+/-)Spi-B(+/+), PU.1(+/-)Spi-B(+/-), and PU.1(+/-) Spi-B(-/-) mice displayed extramedullary splenic hematopoiesis. In summary, PU.1 and Spi-B regulate common target genes required for proliferation of hematopoietic progenitors or their committed descendants, whereas Ets-1 or Elf-1 do not appear to regulate shared target genes with PU.1 or Spi-B.

References

Oct 1, 1992·Molecular and Cellular Biology·D RayF Moreau-Gachelin
Jul 1, 1996·The Journal of Experimental Medicine·G H SuM C Simon
Oct 24, 1998·The Journal of Biological Chemistry·E O BockampA R Green

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Citations

May 7, 2003·International Journal of Hematology·John D Shaughnessy
Jun 7, 2005·Gene·Lee Ann Garrett-SinhaMarcus R Clark
Feb 1, 2003·Gene·Tsuneyuki Oikawa, Toshiyuki Yamada
Nov 30, 2002·Seminars in Immunology·Rebecca H Lian, Vinay Kumar
Nov 26, 2003·Blood Cells, Molecules & Diseases·H Daniel Lacorazza, Stephen D Nimer
Feb 9, 2010·The Journal of Biological Chemistry·Shuyang YuHai-Hui Xue
May 1, 2002·The EMBO Journal·Richard DahlM Celeste Simon
Jan 14, 2003·Annual Review of Immunology·Kathryn L CalameChainarong Tunyaplin
May 10, 2011·Annual Review of Biochemistry·Peter C HollenhorstBarbara J Graves
Dec 13, 2006·Experimental Hematology·Eldar HochmanShai Izraeli
Oct 2, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sune KobberupJan Jensen
Feb 2, 2006·Immunological Reviews·Elizabeth-Sharon David-FungEllen V Rothenberg
Jun 27, 2006·Biochimica Et Biophysica Acta·Xiumei GuoKian-Cheng Tan-Un
Oct 21, 2005·Critical Reviews in Oncology/hematology·Björn SteffenHubert Serve
Feb 4, 2003·Nature Reviews. Cancer·Daniel G Tenen
Aug 28, 2004·Clinics in Chest Medicine·Jeffrey J PresneillJohn F Seymour
Nov 8, 2011·Developmental Biology·William SchachterleBrian L Black
Apr 30, 2016·Angiogenesis·Michael P Craig, Saulius Sumanas
Jul 18, 2016·Biochimica Et Biophysica Acta·Anton M SchwartzDmitry V Kuprash
Jul 20, 2002·Blood·Beatrice U MuellerDaniel G Tenen
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumihiko TakeshitaKen J Ishii
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanbiao GengChyung-Ru Wang
Aug 9, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byunghee KohMark H Kaplan
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juliette M LefebvreDavid L Wiest

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