PU.1/Interferon Regulatory Factor interactions: mechanisms of transcriptional regulation

Cell Biochemistry and Biophysics
S Marecki, M J Fenton

Abstract

The complexity of eukaryotic gene regulation is slowly being resolved. What has become clear is that transcriptional regulation is a multi-step process that involves the assembly of macromolecular complexes. This review will discuss the biology of the ETS family transcription factor PU.1, with emphasis on its interactions with two members of the Interferon Regulatory Factor (IRF) family, interferon consensus sequence binding protein (ICSBP), and IRF-4. The role of these interactions in transcriptional regulation is discussed, with respect to DNA binding motifs, protein-protein interaction and phosphorylation states that modulate PU.1/IRF interactions. Furthermore, potential transcriptional mechanisms for several genes are discussed, focusing on genes involved in innate immunity. Data from these studies suggest at least four distinct paradigms for transcriptional regulation by an ETS protein in conjunction with either ICSBP or IRF-4. These paradigms may describe regulatory mechanisms common to many distinct transcription factor families. Last, recent data from several laboratories have now documented the expression of ICSBP and IRF-4 in a range of cell types. These data suggest that ICSBP and IRF-4 may serve functions within the...Continue Reading

Citations

Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexis Verger, Martine Duterque-Coquillaud
May 4, 2005·The Journal of Experimental Medicine·Aleksandar DakicStephen L Nutt
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yael MamaneJohn Hiscott
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomohiko Tamura, Keiko Ozato
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ben-Zion LeviDavid Meraro
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yuka KannoKeiko Ozato
Mar 24, 2011·International Immunology·Yana Khalfin-RabinovichBen-Zion Levi
Jul 30, 2009·Molecular Biology and Evolution·Jirí NehybaHenry R Bose
Aug 21, 2010·Nucleic Acids Research·Morana VitezicCarsten O Daub
Dec 14, 2002·Blood·Sam J P GobinPeter J Van den Elsen
Jan 13, 2012·PloS One·Theresa J BarberiAnthony R Means
Sep 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Leopoldo Laricchia-RobbioKeiko Ozato
Feb 3, 2007·Trends in Immunology·Aleksandar DakicStephen L Nutt
Apr 23, 2009·Journal of Cellular and Molecular Medicine·Pallavi GuptaRajendra P Tripathi
May 18, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K IekiM Adachi
Jul 20, 2007·European Journal of Immunology·Heng ZengRuxana T Sadikot
Nov 4, 2004·Seminars in Immunology·Ellen V Rothenberg, Rashmi Pant
Apr 7, 2006·Molecular Immunology·Natalie DrorBen-Zion Levi
Jul 6, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandra Mancino, Gioacchino Natoli
Aug 9, 2003·The Journal of Biological Chemistry·Michal Alter-KoltunoffBen-Zion Levi
Mar 16, 2007·Journal of Leukocyte Biology·Kate SchroderMatthew J Sweet
Jul 1, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa BorghiniSonia Davila
Apr 5, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bashar S StaitiehDavid M Guidot
Jul 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya YashiroChiharu Nishiyama
Mar 1, 2003·The Journal of Biological Chemistry·Leonard B MaggiJohn A Corbett
Mar 5, 2004·The Journal of Biological Chemistry·Cheol Kyu HwangHorace H Loh
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyesuk Yoon, Jeremy M Boss
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola MazziStefano Dusi
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne LehtonenIlkka Julkunen
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ying WangManuela Cernadas
Jun 11, 2019·Frontiers in Immunology·Aleksandra AntonczykHans A R Bluyssen
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sonia SharmaJohn Hiscott
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracy C Kuo, Kathryn L Calame

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