PMID: 19912781Feb 1, 1991Paper

Pubertal changes in pro-opiomelanocortin and gonadotropin-releasing hormone gene expression in the brain of the male monkey

Molecular and Cellular Neurosciences
L VicianR A Steiner

Abstract

Puberty in the primate is initiated by an amplification of the pulsatile secretion of gonadotropin-releasing hormone (GnRH); however, the factors responsible for this a pubertal activation of GnRH neurons are unknown. We examined whether the biosynthetic capacity of GnRH neurons could be limiting for GnRH secretion in the juvenile monkey by determining whether the prepubertal macaque (Maraca fascicularis) expresses the GnRH gene. Using in situ hybridization for GnRH mRNA, we found no evidence for differences between prepubertal and adult animals in either the cellular level of GnRH mRNAs or the number of GnRH mRNA-containing cells in any area of the brain. These observations suggest that expression of the GnRH gene, at least to the point of messenger mRNA production, is not limiting for puberty onset. beta-Endorphin, derived from its precursor proopiomelanocortin (POMC), has been implicated as an inhibitory neurotransmitter in the control of GnRH secretion. We examined whether expression of the POMC gene changes as a function of sexual maturation by comparing the cellular content of POMC mRNA in the arcuate nucleus between prepubertal and adult male macaques. We report that cellular POMC mRNA levels are significantly higher in ...Continue Reading

References

Feb 1, 1985·The Journal of Clinical Endocrinology and Metabolism·P M GilbeauC G Smith
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·N MaurasA D Rogol
Dec 1, 1984·Brain Research Bulletin·H KhachaturianS J Watson
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Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·J F RopertS S Yen

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Citations

Feb 1, 1995·Cellular and Molecular Neurobiology·E Terasawa
Sep 1, 1995·Journal of Neuroendocrinology·J W WitkinM Ferin
Oct 1, 1996·Acta Paediatrica. Supplement·T M Plant
Jun 1, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Francis J P Ebling
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·M El MajdoubiT M Plant
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Apr 24, 2018·Frontiers in Endocrinology·Ei TerasawaKim L Keen

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