PMID: 6989643May 15, 1980Paper

Pubertal control mechanisms as revealed from human studies

Federation Proceedings
J J Chipman


Human puberty is thought to be regulated by a central nervous system (CNS) program. Strong presumptive evidence for this thesis has been drawn from the augmented gonadotropin secretion that occurs synchronously with sleep in early puberty and serves as a biologic index to CNS puberty. In response to wake/sleep gonadotropin patterns, sex steroids are also secreted in circadian-like patterns during puberty. In disorders such as precocious puberty, anorexia nervosa, and gonadal dysgenesis, the physiological mechanisms that control wake/sleep differences in gonadotropin secretion appear to be intact. Studies in such patients suggest that the primary sex hormones have a quantitative but not qualitative modulating effect on the CNS program. Possible additional control mechanisms include adrenal androgen secretion and body composition.

Related Concepts

Anorexia Nervosa
Circadian Rhythms
Gonadal Agenesis
Pituitary Gonadotropins
Gonadorelin Hydrochloride
Precocious Puberty
Gonadal Steroid Hormones
Sleep, Slow-Wave

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