Pubertal fenvalerate exposure impairs cognitive and behavioral development partially through down-regulating hippocampal thyroid hormone receptor signaling

Toxicology Letters
Yang YangXiu-Hong Meng

Abstract

Fenvalerate, a synthetic pyrethroid insecticide, is an environmental endocrine disruptor and neurodevelopmental toxicant. An early report found that pubertal exposure to high-dose fenvalerate impaired cognitive and behavioral development. Here, we aimed to further investigate the effect of pubertal exposure to low-dose fenvalerate on cognitive and behavioral development. Mice were orally administered with fenvalerate (0.2, 1.0 and 5.0 mg/kg) daily from postnatal day (PND) 28 to PND56. Learning and memory were assessed by Morris water maze. Anxiety-related activities were detected by open-field and elevated plus-maze. Increased anxiety activities were observed only in females exposed to fenvalerate. Spatial learning and memory were damaged only in females exposed to fenvalerate. Histopathology observed numerous scattered shrinking neurons and nuclear pyknosis in hippocampal CA1 region. Neuronal density was reduced in hippocampal CA1 region of fenvalerate-exposed mice. Mechanistically, hippocampal thyroid hormone receptor (TR)β1 was down-regulated in a dose-dependent manner in females. In addition, TRα1 was declined only in females exposed to 5.0 mg/kg fenvalerate. Taken together, these suggests that pubertal exposure to low-dose...Continue Reading

References

Jan 5, 2000·The American Journal of Psychiatry·J D BremnerD S Charney
Jun 9, 2000·Annual Review of Physiology·J Zhang, M A Lazar
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Oct 8, 2011·PloS One·Jennifer T WolstenholmeEmilie F Rissman
Dec 14, 2011·Current Opinion in Psychiatry·Jozsef Haller, Mano Alicki
Jun 22, 2012·Environment International·Cayo CorcellasDamià Barceló
Sep 5, 2012·The Journal of Clinical Investigation·Gregory A Brent
Feb 14, 2013·Toxicology and Applied Pharmacology·Sara Mostafalou, Mohammad Abdollahi
Apr 10, 2013·Hormones and Behavior·Nandini VasudevanSonoko Ogawa
Jul 19, 2013·Acta Neuropathologica·Peter T NelsonFrederick A Schmitt
Sep 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Karen A WilloughbyJoanne F Rovet
Oct 24, 2013·Environmental Health Perspectives·Youssef Oulhote, Maryse F Bouchard
Nov 12, 2013·Thyroid : Official Journal of the American Thyroid Association·Gillian E CookeJames Gibney
Nov 22, 2014·Environmental Health and Preventive Medicine·Jinky Leilanie Del Prado-Lu
Jan 24, 2015·The International Journal of Neuropsychopharmacology·Masanori OokuboHirohiko Kanai
May 27, 2015·Archives of Environmental Contamination and Toxicology·J S BediPrabhjit Kaur
Dec 22, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Fernando Sánchez-SantedElena Herrero Hernández
Mar 5, 2016·Frontiers in Endocrinology·Julieta E LischinskyJoanne Rovet
Nov 22, 2016·Journal of Neuroscience Research·Bruce S McEwen, Teresa A Milner
Nov 22, 2016·Journal of Neuroscience Research·Tomáš PausZdenka Pausova
Dec 13, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Joachim Krebs
Apr 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bo WangDe-Xiang Xu
Apr 30, 2017·Environment International·Philippe GlorennecCécile Chevrier
May 30, 2017·Environmental Science and Pollution Research International·Salim GasmiBelgacem Djabri
Sep 28, 2017·Journal of Applied Toxicology : JAT·Zheng-Guo CuiHidekuni Inadera
Nov 18, 2017·Chemosphere·Wangxin TangDongyun Yan
Dec 13, 2018·Environmental Science and Pollution Research International·Jingwei ZhangJiazhang Chen
Feb 2, 2019·Ecotoxicology and Environmental Safety·Ce GuoXiu-Hong Meng
Apr 20, 2019·Frontiers in Endocrinology·Barbara K Stepien, Wieland B Huttner

❮ Previous
Next ❯

Citations

Aug 7, 2021·Ecotoxicology and Environmental Safety·Feng ZhanXiu-Hong Meng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.