Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

Translational Psychiatry
Monique ErnstIMAGEN Consortium

Abstract

This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN's function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, p...Continue Reading

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Citations

Feb 2, 2021·Journal of Psychiatric Research·Bothe KathrinHoedlmoser Kerstin
Nov 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Nicole R KarcherDeanna M Barch

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Software Mentioned

3dClustSim
SAS
IMAGEN
3dQwarp
3dmaskave
FreeSurfer
3dFWHMx
AFNI
SPSS
ANATICOR

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