Pubertal testosterone organizes regional volume and neuronal number within the medial amygdala of adult male Syrian hamsters.

Brain Research
Kayla C De LormeCheryl L Sisk

Abstract

The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activational effects of testosterone in adulthood, and any interactions on regional volume and neuronal number of the medial amygdala. Male Syrian hamsters either did or did not experience endogenous testosterone during pubertal brain development, and then received either testosterone-filled or blank capsules during adulthood 2 weeks before tissue collection. The results show that pubertal testosterone has long-term organizational effects on volume of specific subregions of the medial amygdala such that the presence of pubertal testosterone resulted in 1) decreased volume of the anterior ventral amygdala and, to a lesser extent, the anterior dorsal medial amygdala; and 2) increased volume of the posterior dorsal medial amygdala. Both effects were independent of the presence of testosterone during adulthood. Pubertal testosterone also decreased neuronal number in the anterior dorsal medial amygdala, suggesting a possible mecha...Continue Reading

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Citations

Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maarten F ZwartMatthias Landgraf
Apr 10, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kay E HolekampPage E Van Meter
Sep 4, 2013·Hormones and Behavior·Matthew R Green, Cheryl M McCormick
Sep 24, 2014·Hormones and Behavior·Jasmina KercmarGregor Majdic
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Mar 11, 2016·Current Opinion in Neurobiology·Cheryl L Sisk
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Jun 25, 2013·Reproductive Toxicology·Alberto Mantovani, Aleksandra Fucic
Nov 24, 2012·Hormones and Behavior·Cheryl M McCormickRachel A Clark
Jun 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiro SanoSonoko Ogawa
Oct 23, 2016·Environment International·Kathrine Eggers PedersenBjarne Styrishave
Jan 12, 2013·Cells, Tissues, Organs·Barbora FilováJúlius Hodosy
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Oct 17, 2018·Neuroendocrinology·Sakina Mhaouty-KodjaDaphné Capela

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