Pubertal timing and a family history of hypertension: A prospective cohort study

Pediatrics International : Official Journal of the Japan Pediatric Society
Wei ZhengZentaro Yamagata

Abstract

Hypertension is heritable, and genetic factors likely exert an effect since childhood. Puberty is an early life milestone that may relate to adult hypertension. Therefore, this study aimed to examine whether there is an association between a family history of hypertension and pubertal growth. The participants were children from a prospective cohort study called Project Koshu, who were born between 1991 and 1998 in Japan. Data on family history of hypertension, maternal characteristics, birth and early life factors were collected from the questionnaire administered to the mothers at the time of pregnancy registration or medical check-up. Children's age at the peak height velocity ('early' or 'non-early') was calculated from the anthropometric data collected during annual school check-ups. Data on 908 children (479 boys and 440 girls) were included in the analysis; 478 participants had a family history of hypertension. After adjustment for potential confounders (birth month, maternal body mass index, maternal work status, maternal education, and paternal education), 'early' age at peak height velocity was found to be associated with a family history of hypertension [OR = 1.52 (1.04-2.24), p = 0.03] and specifically, with having a...Continue Reading

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Citations

Apr 14, 2021·Biological Trace Element Research·Cailiang ZhangFeng Hong

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