Pubertal Timing and Cardiometabolic Markers at Age 16 Years

The Journal of Pediatrics
Nina E BerentzenHenriëtte A Smit

Abstract

To examine the association between pubertal timing and cardiometabolic markers among adolescents. We used data from Dutch adolescents participating in a birth cohort study. The study population for the current study consisted of 799 adolescents of whom data were available for at least 1 of the exposure variables (pubertal timing and/or age at menarche) and any of the cardiometabolic markers (waist circumference, cholesterol, blood pressure [BP], glycated hemoglobin) measured at age 16 years. Adolescents self-reported pubertal development at ages 11, 14, and 16 years. We categorized participants with early (84 girls, 88 boys), intermediate (240 girls, 211 boys), or late pubertal timing (89 girls, 85 boys). We estimated differences in cardiometabolic markers using linear regression analysis. Girls with early pubertal timing had 1.54 cm larger waist circumference (95% CI .05; 3.03) and 3.98 mm Hg higher systolic BP (95% CI 1.69; 6.27) at age 16 years than girls with intermediate pubertal timing. The association with systolic BP remained after adjusting for childhood body mass index (BMI) (age 8 years) but attenuated after adjusting for BMI in adolescence (age 16 years). Boys with early pubertal timing had 0.79 mmol/mol lower glyca...Continue Reading

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Citations

Jan 10, 2019·International Journal of Epidemiology·Izzuddin M ArisEmily Oken
Sep 27, 2020·Stress and Health : Journal of the International Society for the Investigation of Stress·Tiwaloluwa A AjibewaRebecca E Hasson
Aug 5, 2019·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Maria J FonsecaAna C Santos
Jul 4, 2021·The Journal of Clinical Hypertension·Yanhui LiJun Ma

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