Public- and Private-Sector Contributions to the Research and Development of the Most Transformational Drugs in the Past 25 Years: From Theory to Therapy

Therapeutic Innovation & Regulatory Science
Ranjana ChakravarthyNils Wendel

Abstract

With available funding from the public sector decreasing while medical needs and scientific complexity increase, private-sector collaborations with academia and government have become increasingly key in furthering medical innovation. Nonetheless, some skeptics diminish the contribution of the private sector to the discovery and development of truly innovative drugs on the one hand, while on the other hand they assert that research and development (R&D) of new medicines could and should be exclusively within control (at least financially) of the government. This begs the question, How much government funding would be needed to replace industry new drug R&D spending? We address the respective roles of the private and public sectors in drug development by examining a diverse array of evidentiary materials on the history of 19 individual drugs, 6 drug classes, and 1 drug combination identified as the most transformative drugs in health care over the past 25 years by a survey of over 200 physicians. Only 4 of the individual drugs appear to have been almost completely researched and developed by one sector. One sector or the other, however, did dominate particular phases of the R&D continuum. For example, 54% of basic science milest...Continue Reading

References

Sep 3, 1998·The New England Journal of Medicine·A C GelijnsA J Moskowitz
Nov 9, 2002·American Journal of Therapeutics·Janice M Reichert, Christopher-Paul Milne
Feb 28, 2003·Journal of Health Economics·Joseph A DiMasiHenry G Grabowski
Oct 24, 2007·Clinical Pharmacology and Therapeutics·J A DiMasi, H G Grabowski
Sep 23, 2008·American Journal of Therapeutics·Kenneth A GetzKenneth I Kaitin
Dec 23, 2009·American Journal of Therapeutics·Benjamin ZycherChristopher-Paul Milne
Feb 5, 2010·Clinical Pharmacology and Therapeutics·J A DiMasiA Wilson
Oct 30, 2010·Nature Reviews. Drug Discovery·Robert Kneller
Feb 4, 2011·Health Affairs·Bhaven N Sampat, Frank R Lichtenberg
Feb 11, 2011·The New England Journal of Medicine·Ashley J StevensMark L Rohrbaugh
May 18, 2013·Nature Reviews. Drug Discovery·Aaron S Kesselheim, Jerry Avorn
Feb 1, 2014·Nature Reviews. Drug Discovery·Helene LinckerHans-Georg Eichler
Mar 2, 2016·Journal of Health Economics·Joseph A DiMasiRonald W Hansen

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Citations

Sep 13, 2018·Annual Review of Pharmacology and Toxicology·Marcus C ParrishDaria Mochly-Rosen
Feb 9, 2018·Pharmaceutical Research·Szymon JarosławskiClaude Dussart
Jun 14, 2019·Journal of Medical Economics·Genia Long
Oct 28, 2019·BMJ : British Medical Journal·Rahul K NayakAaron S Kesselheim
Sep 9, 2017·CNS Neuroscience & Therapeutics·Zhi WangChao-Yu Miao
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina Galkina ClearyFred D Ledley
Nov 11, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S Sethu K Reddy, Shing Chao
Nov 19, 2020·F1000Research·Rena M Conti, Frank S David
Apr 30, 2021·Journal of Pharmaceutical Policy and Practice·L SchmidtC Wild
Jun 8, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jeffrey CummingsGaram Lee
Sep 9, 2021·Neurology·Rachel BarenieAaron S Kesselheim

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