Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey

The Lancet Infectious Diseases
Simon R HarrisEuro-GASP study group

Abstract

Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population dynamics and to predict and infer transmission of antimicrobial resistance, and can enhance infection control through linkage with epidemiological data. We used WGS, in conjunction with linked epidemiological and phenotypic data, to describe the gonococcal population in 20 European countries. We aimed to detail changes in phenotypic antimicrobial resistance levels (and the reasons for these changes) and strain distribution (with a focus on antimicrobial resistance strains in risk groups), and to predict antimicrobial resistance from WGS data. We carried out an observational study, in which we sequenced isolates taken from patients with gonorrhoea from the European Gonococcal Antimicrobial Surveillance Programme in 20 countries from September to November, 2013. We also developed a web platform that we used for automated antimicrobial resistance prediction, molecular typing (N gonorrhoeae multi-antigen sequence typing [NG-MAST] and multilocus sequence typing), and phylogenetic clustering in conjunction with epidemiological and phenotypic data. The multidrug-resistant ...Continue Reading

Citations

Jan 31, 2019·Microbial Genomics·Leonor Sánchez-Busó, Simon R Harris
Nov 2, 2018·Journal of Clinical Microbiology·Michelle SuTimothy D Read
Mar 2, 2019·The Journal of Antimicrobial Chemotherapy·Ricardo A GianeciniUNKNOWN Gonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group
Mar 25, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iryna BoikoMagnus Unemo
May 26, 2018·The Journal of Antimicrobial Chemotherapy·Susanne JacobssonMagnus Unemo
Nov 23, 2019·Nature Reviews. Disease Primers·Magnus UnemoJo-Anne R Dillon
May 23, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iryna BoikoMagnus Unemo
Jun 5, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Miguel PintoUNKNOWN PTGonoNet
Aug 14, 2020·The Journal of Antimicrobial Chemotherapy·Daniel GolparianUNKNOWN Brazilian-GASP Network
Sep 7, 2019·Nature Communications·Deborah A WilliamsonBenjamin P Howden
Feb 25, 2020·Emerging Infectious Diseases·Katy TownGwenda Hughes
Aug 8, 2020·Mucosal Immunology·Jonna BisterNiklas K Björkström
Jul 24, 2020·Genome Biology·Gerry Tonkin-HillJulian Parkhill
Sep 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sophia DavidDavid M Aanensen
Feb 19, 2020·The Journal of Antimicrobial Chemotherapy·Pham Thi LanMagnus Unemo
Jun 21, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Anna CarannantePaola Stefanelli
Jul 12, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·David W EyreMonique I Andersson
Jul 31, 2019·Nature Microbiology·Leonor Sánchez-BusóSimon R Harris
Mar 28, 2020·Microbial Genomics·Kristian AlfsnesDominique A Caugant
Jun 13, 2020·Sexually Transmitted Diseases·Miguel PintoMaria José Borrego
Oct 31, 2020·International Journal of STD & AIDS·M UnemoJ S Jensen

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Software Mentioned

Euro
Whole Genome Sequence Analysis
GASP
NG
WGSA
Whole Genome Sequence Analysis ( WGSA )
MLST
BLASTn
TreeBreaker
MAST

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