Public T cell receptor beta-chains are not advantaged during positive selection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Anna FurmanskiJulian Dyson

Abstract

Studies of human and murine T cells have shown that public TCR beta-chain rearrangements can dominate the Ag-specific and naive repertoires of distinct individuals. We show that mouse T cells responding to the minor histocompatibility Ag HYDbSmcy share an invariant Vbeta8.2-Jbeta2.3 TCR gene rearrangement. The dominance of this rearrangement shows that it successfully negotiated thymic selection and was highly favored during clonal expansion in all animals examined. We hypothesized that such beta-chains are advantaged during thymic and/or peripheral selection and, as a result, may be over-represented in the naive repertoire. A sequencing study was undertaken to examine the diversity of Vbeta8.2-Jbeta2.3 CDR3 loops from naive T cell repertoires of multiple mice. Public TCR beta-chain sequences were identified across different repertoires and MHC haplotypes. To determine whether such public beta-chains are advantaged during thymic selection, individual chains were followed through T cell development in a series of novel bone marrow competition chimeras. We demonstrate that beta-chains were positively selected with similar efficiency regardless of CDR3 loop sequence. Therefore, the establishment and maintenance of public beta-chai...Continue Reading

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Citations

Jan 4, 2012·Cell Research·Hanjie LiJiahuai Han
Oct 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen J HollandJulian Dyson
Jan 27, 2015·Cellular & Molecular Immunology·Meriem AttafAndrew K Sewell
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Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa VenturiMiles P Davenport
Feb 9, 2011·Immunology and Cell Biology·John J MilesDavid A Price
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cristina FerreiraJulian Dyson
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Nov 22, 2011·European Journal of Immunology·Anna L FurmanskiTessa Crompton
Jul 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanjie LiJiahuai Han
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Mar 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa VenturiDaniel C Douek
Nov 30, 2018·Frontiers in Immunology·Meriem AttafPhilip Goulder

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