Publication status of completed registered studies in paediatric appendicitis: a cross-sectional analysis

BMJ Open
Thomas BreilMarkus Ries

Abstract

Appendicitis is considered the most frequent surgical emergency in children. While the management of paediatric appendicitis is evolving, the precise amount of unpublished completed trials, potentially introducing bias into meta-analyses, is unknown. Controversial issues include the appropriate choice of surgical procedures, criteria for diagnosis of appendicitis, the role of antibiotic treatment and pain management. Selective reporting may introduce bias into evidence-based clinical decision-making, and the current, precise extent of unpublished results in paediatric appendicitis is unknown. We therefore assessed the publication status of completed clinical studies involving children registered on ClinicalTrials.gov. Cross sectional analysis. STrengthening the Reporting of OBservational studies in Epidemiology criteria were applied for design and analysis. ClinicalTrials.gov was queried for completed studies which were matched to publications on ClinicalTrials.gov, PubMed or Google Scholar. If no publication could be identified, principal investigators were contacted. Observational analysis. The proportion of published and unpublished studies was calculated. Subgroup analysis included studies on surgical procedures, diagnosis,...Continue Reading

References

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Dec 3, 2016·CJEM·Andrea L RobbUNKNOWN Pediatric Emergency Research Canada (PERC) Appendicitis Study Group

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Citations

Jan 9, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sergio ModafferiVerena Peters

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Clinical Trials Mentioned

NCT02311452
NCT02018016
NCT02017951
NCT01054417
NCT01678365
NCT01115153
NCT02730585
NCT01067937
NCT02724410
NCT02673528

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SAS Enterprise Guide
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