Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production

Bioscience, Biotechnology, and Biochemistry
Sanfu LinYunlong Yu

Abstract

Puerarin inhibits osteoclastogenesis and cells migration. This study aims to explore whether puerarin prevents osteoclastogenesis by inhibiting osteoclast precursors (OCPs) migration. The results showed that puerarin reduced MCP-1 production in OCPs, while inhibiting OCPs migration based on MCP-1. Puerarin reversed MCP-1-promoted osteoclastogenesis. CCR2 overexpression didn't increase osteoclastogenesis with puerarin. Therefore, puerarin prevents OCPs migration by reducing MCP-1, whereby inhibiting osteoclastogenesis.

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Citations

Apr 20, 2021·Frontiers in Immunology·Yao YaoMeng Zhang

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Methods Mentioned

BETA
xenograft
ELISA

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