PMID: 9638603Jun 25, 1998Paper

Puerperal and menstrual psychoses: the proposal of a unitary etiological hypothesis

Journal of Psychosomatic Obstetrics and Gynaecology
N Deuchar, I F Brockington

Abstract

Puerperal and menstrual psychoses are both uncommon disorders and the occurrence of both in individual patients suggests the possibility of a common underlying pathogenesis. In this paper two cases are reported, the literature is reviewed and a unifying etiological hypothesis is postulated in which precipitous reductions in the brain estrogen environment precipitate episodes of psychosis in predisposed individuals. In the case of puerperal psychosis, estrogen cascade follows a lengthy period of sustained high brain estrogen environment; in menstrual psychosis, it is postulated that the occurrence in at least some cases of anovulatory menstrual cycles, wherein high levels of relatively unopposed estrogens are maintained until the next ovulatory cycle, play a role in priming the central nervous system prior to premenstrual estrogen cascade. Further research in this area using more sensitive techniques to follow hormonal fluctuation and mental state is called for.

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Citations

Oct 2, 2008·Archives of Women's Mental Health·Christina AndreouAthanasios Karavatos
Apr 2, 2009·Archives of Women's Mental Health·I F Brockington
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·E M ByrnesR S Bridges
Oct 2, 2007·Health Care for Women International·Helen SheinfeldTali Vishne
Oct 1, 2005·International Review of Psychiatry·Victor Peralta, Manuel J Cuesta
Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mary V Seeman
Oct 20, 2009·Psychiatry Research·Marta Coromina SadurniMònica Sánchez Autet
Jan 13, 2012·Acta Psychiatrica Scandinavica·M V Seeman
Dec 18, 2016·Archives of Women's Mental Health·Leah C Susser, Alison D Hermann
Sep 13, 2003·International Journal of Psychiatry in Medicine·Daniel SteinEliezer Witztum
Nov 3, 2011·JRSM Short Reports·John Clifford, Jane Rowland
Nov 24, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Isha Jalnapurkar, Jonathan Chase Findley
Jan 25, 2000·The British Journal of Psychiatry : the Journal of Mental Science·V MaheN Glück
May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·V MaheA Dumane
Nov 28, 2001·Acta Psychiatrica Scandinavica·V Mahé, A Dumaine
Jun 5, 2019·Archives of Women's Mental Health·Heather Burrell WardMarcela Almeida
Jun 27, 2020·Frontiers in Psychiatry·Larissa DorettoAna Cristina Chaves
Mar 9, 2021·Indian Journal of Psychiatry·Rajashree Ray, Imon Paul

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