PMID: 9537466Apr 16, 1998Paper

Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms

The American Journal of Surgical Pathology
Y NakataniEugene J Mark

Abstract

Seven cases of high-grade adenocarcinoma of fetal lung type (H-FLAC) are compared with nine cases of pulmonary endodermal tumor resembling fetal lung or low-grade adenocarcinoma of fetal lung type (L-FLAC). Of the seven patients with of H-FLAC, four were men and three were women. All of the patients but one were in their 60s or 70s. Five patients were smokers. After resection of the tumor, three patients died of metastases, two patients are alive with no evidence of disease, and two patients died of a postoperative complication. Histologically, H-FLAC and L-FLAC have both complex glandular structures resembling fetal lung and neuroendocrine differentiation. Two cases of H-FLAC had stromal proliferation typical of biphasic pulmonary blastoma. The H-FLAC was distinguished from L-FLAC by the presence of disorganized glands, large vesicular nuclei, prominent nucleoli, pronounced anisonucleosis, absence of morules, transition to conventional adenocarcinoma, broad areas of necrosis, desmoplastic stroma, overexpression of p53 protein, and production of alpha-fetoprotein. High and low grades of FLAC explain discrepancies in previously reported clinicopathologic features of FLAC. The H-FLAC needs to be distinguished from L-FLAC. Both fo...Continue Reading

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Citations

Feb 17, 2005·Pediatric Blood & Cancer·Dave R LalMichael P La Quaglia
Jan 2, 2014·Cancer Investigation·Cecilia MennaMohsen Ibrahim
Jan 1, 2014·Thoracic Cancer·Raffaele GiustiPaolo Marchetti
Aug 15, 2018·Thoracic Cancer·Tadashi SakaneRyoichi Nakanishi
Jul 20, 2013·Pathology International·Kae KawachiAkinori Nozawa
Aug 13, 2005·The American Journal of Surgical Pathology·Francisco F NogalesTalina González
Jan 7, 2009·International Journal of Surgical Pathology·Giuseppe PelosiJuan Rosai
Jun 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Clément J R HuysentruytKoen K Van de Vijver
Jun 19, 2018·Advances in Anatomic Pathology·Annikka Weissferdt
May 23, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masaki SuzukiTomoyuki Yokose
Apr 1, 2020·Thoracic Cancer·Hironori IshidaYoshihiko Shimizu
May 20, 2003·The Journal of Pathology·Shigeki SekineSetsuo Hirohashi
Jul 28, 2005·Histopathology·J R SteinhauerS Suster
Apr 10, 2002·Pathology International·Kenzo HiroshimaHidemi Ohwada
Nov 23, 2010·American Journal of Clinical Pathology·Kim R GeisingerMaureen F Zakowski
Jun 16, 2015·Case Reports in Oncological Medicine·Shinya SakataHirotsugu Kohrogi
Feb 7, 2014·Fukushima Journal of Medical Science·Ryuzo KannoMitsukazu Gotoh
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Oct 28, 2020·The Journal of International Medical Research·Zhuanbo LuoKejing Ying
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Sep 1, 2021·Thoracic Cancer·Shuyang ZhangYan Wang
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Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Dec 1, 2021·Virchows Archiv : an International Journal of Pathology·Satsuki KishikawaTakashi Yao

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