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Pulmonary aerosol actions of LY188695 (KB2413), a new potent H1-receptor antagonist

Agents and Actions

Jun 1, 1987

S A SilbaughL E Rinkema

Abstract

The new potent H1 receptor antagonist, LY188695 (KB2413), was delivered to guinea pigs as a pulmonary aerosol and its ability to inhibit histamine-induced airway obstruction examined. Aerosol LY188695 was more effective than inhaled chlorpheniramine or clemastine in reducing the pulmona...read more

Mentioned in this Paper

Histamine Measurement
Histamine-1 Receptor Antagonist [EPC]
Lung
Cavia
Intravenous Injections
Antagonist Muscle Action
Kloromin
Broncholytic Effect
Bronchial Provocation Tests
Antihistamine [EPC]
Paper Details
References
  • References12
  • Citations4
1

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Pulmonary aerosol actions of LY188695 (KB2413), a new potent H1-receptor antagonist

Agents and Actions

Jun 1, 1987

S A SilbaughL E Rinkema

PMID: 2888282

DOI: 10.1007/bf01974926

Abstract

The new potent H1 receptor antagonist, LY188695 (KB2413), was delivered to guinea pigs as a pulmonary aerosol and its ability to inhibit histamine-induced airway obstruction examined. Aerosol LY188695 was more effective than inhaled chlorpheniramine or clemastine in reducing the pulmona...read more

Mentioned in this Paper

Histamine Measurement
Histamine-1 Receptor Antagonist [EPC]
Lung
Cavia
Intravenous Injections
Antagonist Muscle Action
Kloromin
Broncholytic Effect
Bronchial Provocation Tests
Antihistamine [EPC]

Similar Papers Found In These Feeds

American Thoracic Society: Clinical Problems

This feed has been developed in conjunction with the American Thoracic Society for the benefit of its Clinical Problems Assembly. It highlights new and impactful papers on clinical therapeutics, diagnoses, and practices pertaining to respiratory disease.

Pharmacological Treatment of Allergies

Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. There are various pharmacological treatments for allergy including antihistamines, anti-cholinergics, decongestants, etc. Discover the latest research on pharmacological treatment of allergies here.

Related Papers

Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology

Evaluation of ulcerogenic effects

Pharmacology & Therapeutics. Part B: General & Systematic PharmacologyJanuary 1, 1979
R Menassé
Paper Details
References
  • References12
  • Citations4
1
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