Pulmonary and right ventricular dysfunction are frequently present in heart failure irrespective of left ventricular ejection fraction

Heart Asia
Wouter RobaeysHans-Peter Brunner-La Rocca

Abstract

Heart failure (HF) may influence the lungs and vice versa. However, this interaction and the influence on right ventricular function (RVF) are insufficiently described in patients with HF divided into the recent groups based on left ventricular ejection fraction (LVEF): HF with reduced, midrange and preserved ejection fraction (HFrEF, HFmrEF and HFpEF, respectively). Overall, 186 consecutive stable patients with HF seen in our outpatient clinic were retrospectively divided into HFrEF (n=70), HFmrEF (n=55) and HFpEF (n=61). Airflow limitation and gas exchange disturbance were measured by spirometry (forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) (%)) and diffusion capacity of the lungs for carbon monoxide (DLCO). Standard echocardiography was performed to measure RV structure (RV diameter) and function (tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP)). Correlations were used to assess possible relations between pulmonary dysfunction and measurements of the RV. None of the investigated parameters differed significantly between the three groups (all p>0.1); FEV1/FVC was 70%±12%, 70%±13% and 74%±10% in patients with HFrEF, HFmrEF and HFpEF (p=0.12) and DLCO w...Continue Reading

References

Nov 1, 1988·Journal of Applied Physiology·L S InselmanH Spencer
Feb 22, 2001·Circulation·R L Johnson
Jan 10, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jens-Uwe VoigtWerner G Daniel
Nov 27, 2002·The European Respiratory Journal·J A HardieO Mørkve
Jan 3, 2006·The European Respiratory Journal·K R ChapmanR Beasley
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Jan 15, 2008·Obesity Surgery·Gerald S ZavorskyNicolas V Christou
Jan 27, 2009·European Journal of Heart Failure·Nathaniel Mark HawkinsJohn J V McMurray
Apr 3, 2010·PLoS Medicine·UNKNOWN PLoS Medicine Editors
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Dec 4, 2012·European Respiratory Review : an Official Journal of the European Respiratory Society·Marco Guazzi, Nazzareno Galiè
Jul 9, 2013·Journal of the American College of Cardiology·Janne Mykland HildeKjetil Steine
Mar 1, 1993·The European Respiratory Journal·J E CotesJ C Yernault
Apr 2, 2014·The European Respiratory Journal·Rogerio SouzaMarius M Hoeper
Jun 4, 2016·JACC. Heart Failure·Thomas P OlsonBarry A Borlaug
Jun 4, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Giovanna PelàAlfredo Chetta

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