Pulmonary and serum surfactant phospholipids and serum catecholamines in strangulation. An experimental study on rats

Forensic Science International : Synergy
J HirvonenP Huttunen

Abstract

Elevations of phospholipid and catecholamine concentrations in the blood are regarded as the vital reactions in asphyxial deaths, which leave few or no morphological signs in the body. These vital reactions were tested here, under strict experimental conditions, employing rapid asphyxia. Rats anaesthetized with barbiturate were strangled with a rope 2 mm thick tightened with a force of 29.4 N (3 kp). The main surfactant components, phosphatidyl choline and phosphatidyl ethanol amine, were measured in serum and lung samples, and catecholamines in the serum. The lungs were also investigated histologically. The serum phospholipid concentration in the strangulated rats was 1.36 +/- 0.32 g/l, versus 1.04 +/- 0.17 g/l in the controls (barbiturate intoxication), P < 0.001, but no change in their content was observed in the lungs (26.21 +/- 4.04 mg/g vs. 25.15 +/- 3.64 mg/g dry weight). Histologically, focal emphysema and tiny haemorrhages were seen in the lungs of both groups with similar frequency. Mean serum noradrenaline (NA) and adrenaline (A) concentrations were significantly higher in the strangulation group (NA = 5.4 +/- 2.6 ng/ml vs. 2.8 +/- 0.1 ng/ml, P < 0.001 and A = 6.0 +/- 3.4 ng/ml vs. 3.8 +/- 3.0 ng/ml, P < 0.05). The r...Continue Reading

References

Aug 1, 1989·Forensic Science International : Synergy·H TakahashiN Tabata
Feb 1, 1985·Forensic Science International : Synergy·M MoritaA Maya
Jan 1, 1996·International Journal of Legal Medicine·J Hirvonen, P Huttunen

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Citations

Feb 13, 2010·International Journal of Legal Medicine·Theresa StrunkBernd Brinkmann
Nov 1, 2000·Forensic Science International : Synergy·G VacchianoR Torino
Mar 15, 2001·Forensic Science International : Synergy·B L ZhuT Tsuji
Aug 28, 1999·Forensic Science International : Synergy·W P TormeyR J FitzGerald
Mar 8, 2000·Forensic Science International : Synergy·K IshidaH Maeda
Oct 20, 2014·Forensic Science, Medicine, and Pathology·Wolf SchweitzerSebastian Winklhofer
Feb 12, 2021·International Journal of Molecular Sciences·Ourania S KotsiouKonstantinos I Gourgoulianis
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enrica RosatoCristian D'Ovidio

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