Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide.

American Journal of Physiology. Heart and Circulatory Physiology
Adeleke M BadejoPhilip J Kadowitz

Abstract

BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). Responses to intravenous injections of BAY 41-8543 were investigated under baseline and elevated tone conditions and when NO synthase (NOS) was inhibited with N(ω)-nitro-L-arginine methyl ester (L-NAME). Under baseline conditions, intravenous injections of BAY 41-8543 caused small decreases in pulmonary arterial pressure, larger decreases in systemic arterial pressure, and increases in cardiac output. When pulmonary arterial pressure was increased to ∼30 mmHg with an intravenous infusion of U-46619, intravenous injections of BAY 41-8543 produced larger dose-dependent decreases in pulmonary arterial pressure, and the relative decreases in pulmonary and systemic arterial pressure in response to the sGC stimulator were similar. Treatment with L-NAME markedly decreased responses to BAY 41-8543 when pulmonary arterial pressure was increased to similar values (∼30 mmHg) in U-46619-infused and in U-46619-infused plus L-NAME-treated animals. The intravenous injection of a small dose of sodium nitroprusside (SNP) when combined with BAY 41-8543 enhanced pulmonary and systemic vasodilator responses to the sGC stimulator in L-NAME-treated animals. ...Continue Reading

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Citations

Dec 13, 2012·Current Hypertension Reports·Robrecht ThoonenEmmanuel S Buys
Jan 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Edward A PankeyPhilip J Kadowitz
Apr 7, 2012·Critical Care Research and Practice·Bobby NossamanPhilip Kadowitz
May 25, 2011·Circulation·Johannes-Peter StaschOleg V Evgenov
Mar 29, 2012·Canadian Journal of Physiology and Pharmacology·David B CaseyPhilip J Kadowitz
Oct 30, 2015·International Journal of Impotence Research·A S Leitão JuniorN R F Nascimento
Apr 3, 2012·Nitric Oxide : Biology and Chemistry·Bobby D NossamanPhilip J Kadowitz
Jan 21, 2012·BJU International·Serap GurWayne J G Hellstrom
Nov 12, 2014·Pflügers Archiv : European journal of physiology·Ludovic WaeckelMichel Félétou
May 5, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Alessio AlognaHeiner Post
Apr 23, 2011·Expert Review of Respiratory Medicine·George F LaskerPhilip J Kadowitz
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·George F LaskerPhilip J Kadowitz

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