PMID: 8957371Dec 1, 1996Paper

Pulmonary arterial endothelial dysfunction potentiates hypercapnic vasoconstriction and alters the response to inhaled nitric oxide

The Annals of Thoracic Surgery
J L MyersR A Hopkins

Abstract

Pulmonary hypertensive crisis can be initiated by episodes of hypercapnic acidosis. Hypercapnic vasoconstriction in the newborn pulmonary arterial circulation may be modulated by endogenous production of nitric oxide (NO) by the endothelial cell and effectively treated with inhalation of NO. Sixteen 48-hour-old piglets were randomized to receive a hypercapnic challenge after administration of either saline vehicle or the NO synthase inhibitor N-omega-nitro-L-arginine (L-NA). Pulmonary arterial pressure, flow, and radius measurements were taken at baseline, after infusion of vehicle or L-NA, during hypercapnia (inspired fraction of carbon dioxide, 0.15), and during inhalation of NO (100 ppm). Fourier analysis was used to calculate input mean impedance, reflecting distal arteriolar vasoconstriction, and characteristic impedance, reflecting proximal arterial geometry and distensibility. Input mean impedance was increased with L-NA administration. Animals pretreated with L-NA also underwent a much larger increase in input mean impedance with exposure to hypercapnia than untreated animals. Characteristic impedance increased in the treated animals, but not in the controls. In the newborn pulmonary arterial circulation, endogenous NO ...Continue Reading

References

Jul 11, 1992·The Annals of Thoracic Surgery·D R JobesW I Norwood
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R A HopkinsJ Stark
Aug 1, 1991·Pediatric Research·T M Zellers, P M Vanhoutte
Aug 1, 1985·Anesthesia and Analgesia·R N Sladen
Sep 1, 1966·Circulation Research·W R MilnorJ D Bargainer
Oct 1, 1994·The Annals of Thoracic Surgery·J R Van CampF M Lupinetti
Jun 1, 1994·The Journal of Clinical Investigation·J R FinemanS J Soifer

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Citations

Jul 8, 1998·Pediatric Clinics of North America·L D Nelin, G M Hoffman
Jun 5, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Tiberiu EzriAmram J. Cohen

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