Pulmonary arterial hypertension in pregnancy-a systematic review of outcomes in the modern era.

Pulmonary Circulation
Ting-Ting LowCandice K Silversides

Abstract

Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade. We searched for articles describing outcomes in pregnancy cohorts published between 2008 and 2018. A total of 3658 titles were screened and 13 studies included for analysis. Pooled incidences and percentages of maternal and perinatal outcomes were calculated. Results showed that out of 272 pregnancies, 214 pregnancies advanced beyond 20 gestational weeks. The mean maternal age was 28 ± 2 years, mean pulmonary artery systolic pressure on echocardiogram was 76 ± 19 mmHg. Etiologies include idiopathic pulmonary arterial hypertension (22%), congenital heart disease (64%), and others (15%). Majority (74%) had good functional class I/II. Only 48% of women received pulmonary arterial hypertension-specific therapy. Premature deliveries occur in 58% of pregnancies at mean of 34 ± 1 weeks, most (76%) had Cesarean section. Maternal mortality rate was 12% overall (n = 26); even higher for idiopathic pulmonary arterial hypertension etiology alone (20%). Reported causes of death included right heart failure, ...Continue Reading

References

Jun 17, 1998·Journal of the American College of Cardiology·B M WeissO M Hess
Jan 17, 2009·European Heart Journal·Elisabeth BédardMichael A Gatzoulis
Apr 9, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·D G KielyC A Elliot
Jun 28, 2011·American Journal of Respiratory and Critical Care Medicine·Marius M Hoeper, John Granton
Jan 28, 2012·The European Respiratory Journal·Xavier JaïsMarius M Hoeper
Mar 7, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·R A CurryM R Johnson
Jul 13, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinji KatsuragiTomoaki Ikeda
Aug 1, 2012·Pulmonary Medicine·Adel M Bassily-MarcusErnest Benjamin
Nov 2, 2012·The European Respiratory Journal·Dror RosengartenMordechai R Kramer
Feb 27, 2013·Archives of Gynecology and Obstetrics·Murali SubbaiahNeeta Singh
Dec 21, 2013·Journal of the American College of Cardiology·Gerald SimonneauRogiero Souza
Apr 2, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Petronella G PieperElke S Hoendermis
May 9, 2015·Journal of the American College of Cardiology·Vallerie V McLaughlinMarc Humbert
Jul 23, 2016·Journal of the American College of Cardiology·Uri ElkayamCandice K Silverside
Nov 18, 2016·BMC Pregnancy and Childbirth·Ruiqi DuanMingrong Xi
Dec 3, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Karen M Olsson, Richard Channick
Feb 9, 2017·Obstetrics and Gynecology·Marie-Louise MengElena Reitman
Oct 27, 2017·Journal of the American Heart Association·Erin ThomasKathleen Stergiopoulos
May 26, 2018·Journal of the American College of Cardiology·Candice K SilversidesSamuel C Siu
Dec 16, 2018·The European Respiratory Journal·Nazzareno GalièGerald Simonneau

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