PMID: 19942562Nov 28, 2009Paper

Pulmonary arterial hypertension: many years' experience and modern approach to a malignant disease in a pulmonary hypertension centre

Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē
Panagiotis KaryofillisDennis V Cokkinos

Abstract

The aim of this study was to record the results from a modern diagnostic and therapeutic approach to patients with pulmonary arterial hypertension. We studied the clinical characteristics and the treatment of 69 patients (50 women, 72.5%), aged 44 +/- 17 years, who were diagnosed with pulmonary hypertension (World Health Organisation categories I, IV and V). The patients' outcomes were recorded over 14 years' operation of our Pulmonary Hypertension Unit. Twenty-seven patients (39.1%) suffered from idiopathic pulmonary hypertension, 12 (17.4%) from thromboembolic obstructive disease, 14 (20.3%) from congenital heart diseases, 11 (15.9%) from connective tissue diseases, 3 (4.3%) from portal hypertension, 2 (2.9%) from sarcoidosis, and 1 (1.4%) from pulmonary veno-occlusive disease. Six patients (8.7%) were in New York Heart Association (NYHA) functional class I, 28 (40.6%) were in class II, 30 (43.5%) were in class III, and 5 (7.2%) were in class IV. Thirty-four patients completed a 6-minute walk test and covered a mean distance of 352 +/- 137 m. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured in 18 patients, with a mean value of 1665 +/- 1935 pg/ml. A vasoreactivity test in 41 patients had a positive re...Continue Reading

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