PMID: 16613346Apr 15, 2006Paper

Pulmonary artery sarcoma: a clinicopathologic and immunohistochemical study of 12 cases

American Journal of Clinical Pathology
Lei HuoSaul Suster

Abstract

We report 12 cases of pulmonary artery sarcoma. The mean age at diagnosis was 48.4 years. Based on histomorphologic features and immunohistochemical findings, 2 tumors were classified as rhabdomyosarcoma, 4 as leiomyosarcoma, 1 as osteogenic sarcoma, 1 as angiosarcoma, and 4 as high-grade sarcoma. All patients underwent surgery. In addition, 7 patients received neoadjuvant or adjuvant therapy. Five patients died 3 to 23 months after surgery. Three patients were still alive at 8, 27, and 68 months at last follow-up. Another 3 patients were alive at 2, 15, and 40 months and then lost to follow-up. The 2 patients with the longest survival (40 months and 68 months) had a diagnosis of leiomyosarcoma. Both patients with rhabdomyosarcoma died at 3 months after surgery. Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed.

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Citations

Jul 8, 2011·Case Reports in Oncology·Motohisa YamasakiNaohiko Inase
Apr 4, 2008·Journal des maladies vasculaires·N BourryL Boyer
Jan 11, 2014·Pathology, Research and Practice·In Ho ChoiJoungho Han

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