Pulmonary biochemical effects of inhaled phosgene in rats

Journal of Toxicology and Environmental Health
S Franch, G E Hatch

Abstract

Three exposure regimens were used to study the time course of indicators of lung damage and recovery response to single or repeated exposures to phosgene (COCl2). Rats were sacrificed immediately or throughout a 38-d recovery period after inhalation of 1 ppm COCl2 for 4 h, at intervals during a 7-h exposure to 1 ppm phosgene, or at several time points throughout a 17-d exposure to 0.125 and 0.25 ppm COCl2 (4 h/d, 5 d/wk) and during a 21-d recovery period. Regimen 1 revealed significantly elevated lung wet weight, lung nonprotein sulfhydryl (NPSH) content, and glucose-6-phosphate dehydrogenase (G6PD) activity that stayed elevated for up to 14 d. A significant decrease in body weight and food intake was observed 1 d after exposure. Regimen 2 caused a slight depression in NPSH content but did not affect G6PD activity. Regimen 3 animals showed sustained elevations in lung wet weight, NPSH content, and G6PD activity after 7 d of exposure. No significant changes in these endpoints were observed for the 0.125 ppm COCl2 group. No consistent elevation in hydroxyproline content was seen at either exposure concentration. Light microscopic examination of lung tissue exposed to 0.25 ppm COCl2 for 17 d revealed moderate multifocal accumulati...Continue Reading

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Citations

Jan 1, 1986·Journal of Toxicology and Environmental Health·G E HatchJ A Graham
Oct 1, 1991·Journal of Toxicology and Environmental Health·J P Ehrlich, G R Burleson
Oct 16, 2009·Inhalation Toxicology·Dana GlassFemi Adeshina
Apr 29, 2008·Regulatory Toxicology and Pharmacology : RTP·Jeffrey S GiftBabasaheb Sonawane
Dec 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsay Wichers StanekDaniel L Costa
Jan 24, 2003·Toxicology and Industrial Health·G HatchD Costa

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