Pulmonary blastoma: an ultrastructural and immunohistochemical study with special reference to nuclear filament aggregation

Ultrastructural Pathology
P YangK Hizawa

Abstract

A case is presented of pulmonary blastoma occurring in the right upper lobe of a 25-year-old man without distinct clinical features and laboratory abnormality. Light microscopic analysis revealed that the tumor was composed of branching glands and morulae embedded in a primitive but bland mesenchyme. Immunohistochemically the epithelial cells were immunoreactive for cytokeratins, S-100 protein, protein gene product 9.5, chromogranin A, calcitonin, and Ki-67 (MIB-1); the mesenchymal cells were immunoreactive for vimentin, actin, cytokeratins, and Ki-67; and all the tumor cells were negative for p53, estrogen receptor protein, and human chorionic gonadotropin beta. Characteristically, many epithelial cells contained optically clear nuclei which were immunoreactive for biotin (M743). Electron microscopic analysis revealed that the optically clearing change was due to replacement of the central area of the nuclei by a mass of parallel-arranged 7- to 10-nm filaments, and biotin-immunoreactive products were mainly localized in the nuclear matrix. Additionally, spherical bodies were identified in the cytoplasm of the nuclear filament-aggregated cells, suggestive of an intimate pathogenetic association of the two morphological abnormal...Continue Reading

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Citations

Jul 31, 2013·Pathology, Research and Practice·Saori KobayashiHitoshi Tsuda
Feb 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Chiun Chei LiToshiaki Sano
Aug 21, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rosa CamerlingoGiuseppe Pirozzi
May 16, 1998·The Journal of Pathology·P YangT Sano
Jul 1, 1997·The American Journal of Surgical Pathology·P YangT Sano
Mar 17, 1999·The American Journal of Surgical Pathology·A SasakiI Nakayama

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