Pulmonary blood volume variation decreases after myocardial infarction in pigs: a quantitative and noninvasive MR imaging measure of heart failure

Radiology
Martin UganderHåkan Arheden

Abstract

To prospectively evaluate the usefulness of magnetic resonance (MR) imaging for estimating pulmonary blood volume (PBV) and the variation in PBV throughout the cardiac cycle in experimental heart failure. The animal care committee approved this prospective study. Seven pigs were studied before and after myocardial infarction. PBV measurement was validated in a phantom and calculated as the product of cardiac output determined with velocity-encoded MR imaging and the pulmonary transit time for an intravenous bolus of contrast material to pass through the pulmonary circulation. The difference in arterial and venous pulmonary flow during the cardiac cycle was integrated for calculation of the PBV variation (expressed as percentage of stroke volume). Differences were evaluated with the Wilcoxon test. Calculated and direct phantom measurements of PBV differed by a mean of 4% +/- 3 (standard deviation) (R(2) = 0.97, P < .001). Infarction induced a decrease in left ventricular stroke volume (44 mL +/- 6 vs 27 mL +/- 7; P = .02), ejection fraction (55% +/- 5 vs 41% +/- 4; P = .02), and PBV variation (61% +/- 12 vs 43% +/- 15; P = .04) but not PBV (225 mL +/- 23 vs 211 mL +/- 42; P = .50). The mean pulmonary artery pressure increased af...Continue Reading

References

Feb 1, 1992·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·M NitzanR Chisin
Sep 1, 1987·Journal of Computer Assisted Tomography·D N FirminD B Longmore
Aug 27, 1970·The New England Journal of Medicine·H J SwanD Chonette
Jul 1, 1971·Circulation Research·S R Reuben
Dec 18, 1965·British Medical Journal·S B RoyM L Bhatia
Nov 1, 1994·Physiological Measurement·M NitzanR Chisin
Aug 9, 2001·European Heart Journal·W J RemmeUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure, European Society of Cardiology
Sep 8, 2001·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·N G BellengerD J Pennell
Jan 29, 2003·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Dudley J Pennell
Oct 1, 1952·American Heart Journal·J T DOYLEE B KELLEY
Jul 1, 1960·Circulation·W R MILNORC J MCGAFF
Mar 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Marcus CarlssonHakan Arheden
Oct 14, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Massimo MischiErik H Korsten
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Søren MøllerJens O Lund
Jun 21, 2007·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alexander ChernobelskySteven D Wolff
Nov 3, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Martin UganderHakan Arheden

❮ Previous
Next ❯

Citations

Sep 27, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Mikael KanskiMartin Ugander
Jul 13, 2013·Critical Care : the Official Journal of the Critical Care Forum·Alessandro ProttiLuciano Gattinoni
Oct 19, 2013·Cardiovascular Ultrasound·Ingeborg H F HeroldHendrikus H M Korsten
Apr 4, 2013·Current Opinion in Cardiology·Samuel WonDavid A Bluemke
Aug 13, 2015·Intensive Care Medicine Experimental·Alessandro ProttiLuciano Gattinoni
Aug 19, 2011·Journal of Pharmacological and Toxicological Methods·MingDe LinG Allan Johnson
Feb 24, 2015·IEEE Transactions on Bio-medical Engineering·Steven M BoronyakW David Merryman
Sep 11, 2019·European Heart Journal Cardiovascular Imaging·Fabrizio RicciSteffen E Petersen
Nov 12, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Björn WieslanderMartin Ugander
Jun 11, 2017·Echocardiography·Anouk G W de LepperPatrick Houthuizen
Jun 21, 2021·JACC. Cardiovascular Imaging·Fabrizio Ricci, Mohammed Y Khanji

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved