PMID: 8594029Nov 1, 1995Paper

Pulmonary chemoreflex sensitivity is enhanced by prostaglandin E2 in anesthetized rats

Journal of Applied Physiology
L Y Lee, R F Morton

Abstract

Stimulation of vagal pulmonary C-fiber afferents by chemical irritants is believed to be responsible for eliciting the pulmonary chemoreflex (apnea, bradycardia, and hypotension). This study was carried out in anesthetized Sprague-Dawley rats to determine whether the pulmonary chemoreflex was altered by prostaglandin E2 (PGE2), which is one of the major inflammatory mediators in the lungs and is known to enhance the sensitivity of C-fiber afferents in several other organ systems. Capsaicin injected at a dose just above the stimulation threshold (0.25 or 0.5 microgram/kg i.v.) elicited a very mild respiratory and cardiovascular depression. In sharp contrast, during a constant infusion of PGE2 (1.5 micrograms.kg-1.min-1 i.v.), the same dose of capsaicin triggered a long apnea, with the expiratory duration reaching 843% of the baseline expiratory duration, accompanied by intense bradycardia and hypotension. Similarly, the pulmonary chemoreflex response elicited by a bolus injection of phenyl biguanide (1 or 2 micrograms/kg i.v.) was also greatly augmented by PGE2. These enhanced responses were completely abolished, by a perineural capsaicin treatment of both cervical vagi to selectively block the conduction of C fibers, suggesting...Continue Reading

Citations

Feb 6, 1998·Journal of Applied Physiology·C J Lai, Y R Kou
Dec 1, 1998·British Journal of Pharmacology·H P KuoL C Lu
Feb 13, 2009·Allergy·I Tillie-LeblondP Chanez
Mar 10, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo ZhuangFadi Xu
May 12, 2019·The Journal of Physiology·J Shane HooperThomas E Taylor-Clark
Mar 2, 1999·The Journal of Physiology·M A NaultJ T Fisher
Dec 1, 1996·Journal of Applied Physiology·L Y LeeJ M Lundberg
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·Z X WuL Y Lee
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·H P KuoL C Lu
Jan 18, 2003·American Journal of Respiratory and Critical Care Medicine·You Shuei LinLu-Yuan Lee
Feb 4, 2006·Journal of Applied Physiology·Dale R Bergren
Apr 1, 2006·Journal of Applied Physiology·Rurong Wang, Fadi Xu
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D E James, F P Nijkamp
Sep 7, 2001·Environmental Health Perspectives·J Widdicombe, L Y Lee
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chun-Chun HsuLu-Yuan Lee
Sep 18, 2002·Journal of Applied Physiology·Kevin Kwong, Lu-Yuan Lee
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·C Y HoL Y Lee
Nov 24, 1999·The American Journal of Physiology·P S ChahalJ C Longhurst
Oct 18, 2000·European Journal of Pharmacology·A D KraneveldF P Nijkamp
Sep 20, 2001·International Immunopharmacology·A D Kraneveld, F P Nijkamp
Oct 31, 2008·Revue des maladies respiratoires·D MontaniP Chanez

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