PMID: 9441122Jun 1, 1997Paper

Pulmonary dysanapsis, methacholine airway responsiveness and sensitization to airborne antigen

Respirology : Official Journal of the Asian Pacific Society of Respirology
M MunakataY Kawakami

Abstract

Whether the disproportional growth of airways relative to lung parenchyma (dysanapsis) has any relationship to the development of non-specific bronchial hyperresponsiveness and atopy was investigated in 45 family members of the patients with atopic asthma. As indices of pulmonary dysanapsis, forced expiratory flow25-75/forced vital capacity (FEF25-75/FVC) and the tracheal cross sectional area divided by the forced expiratory volume (X-SA/FVC) were examined. As an index of non-specific airway responsiveness, the cumulative dose of inhaled methacholine needed to induce 35% reduction of respiratory conductance (PD35) was determined by continuous respiratory resistance measurement. For examination of atopy, skin prick tests were conducted, and total serum IgE and IgE specific to common inhaled antigens were measured. FEF25-75/FVC showed no significant correlation to FVC but showed a significant correlation to log(PD35). When the analysis was done in the subjects whose FEV1/FVC was more than 0.8, FEF25-75/FVC showed a significant negative correlation to FVC but lost its correlation to log(PD35). X-SA/FVC showed a significant negative correlation to FVC but had no significant correlation to log(PD35). These relations were conserved w...Continue Reading

References

Apr 1, 1991·Journal of Applied Physiology·Y KawakamiH Kusaka
Dec 1, 1989·The American Review of Respiratory Disease·G T O'ConnorS T Weiss
Apr 1, 1987·The American Review of Respiratory Disease·B BurrowsM D Lebowitz
Aug 1, 1986·Journal of Applied Physiology·Y KawakamiS Abe
Jul 1, 1974·Journal of Applied Physiology·M GreenJ M Turner
Jun 1, 1968·The Journal of Clinical Investigation·G GrimbyJ Mead

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Citations

Nov 26, 2015·Clinics in Perinatology·Thomas J Mariani
Oct 18, 2016·Pediatric Pulmonology·Sarah J KotechaSailesh Kotecha
Mar 22, 2005·Pulmonary Pharmacology & Therapeutics·Richard W ChapmanChander Celly

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